Detection of epstein-barr virus-derived latent membrane protein-1 gene in various head and neck cancers: Is it specific for nasopharyngeal carcinoma?

Ngan Ming Tsang, Kai Ping Chang, Shinn Yn Lin, Sheng Po Hao, Chen Kan Tseng, Tseng tong Kuo, Ming Hsui Tsai, Tsao Chuen Chung

Research output: Contribution to journalArticle

23 Citations (Scopus)


Objective: The object of the study was to determine the incidence of the presence of Epstein-Barr virus-derived latent membrane protein-1 (LMP-1) gene in various head and neck cancers by polymerase chain reaction method. Study Design: Prospective study. Methods: During a 5-year period, polymerase chain reaction was used to investigate the presence of LMP-1 gene in various head and neck cancers from different locations and histopathological types, non-cancerous nasopharyngeal biopsy samples, and tonsillectomy specimens from patients with chronic hypertrophic tonsillitis. Results: Of 202 patients enrolled in the study, 53 were diagnosed by pathological study with oropharyngeal carcinoma, 45 with nasopharyngeal carcinoma, 26 with oral cavity carcinoma, 26 with laryngohypopharyngeal carcinoma, 31 with nasopharyngeal lymphoid hyperplasia, and 21 with tonsils with lymphoid hyperplasia. After the application of polymerase chain reaction, the LMP-1 gene was not detected in any sample from oral cavity carcinoma, laryngohypopharyngeal carcinoma, or nasopharyngeal lymphoid hyperplasia or from tonsillectomy specimens but was detected in only one case of tonsillar carcinoma. On the contrary, the LMP-1 gene was detected in 43 (95.6%) of 45 samples from patients with nasopharyngeal carcinoma. The statistical analysis shows a significant association (P

Original languageEnglish
Pages (from-to)1050-1054
Number of pages5
Issue number6
Publication statusPublished - Jun 1 2003



  • Epstein-Barr virus
  • Head and neck
  • Latent membrane protein-1
  • Nasopharyngeal carcinoma
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Otorhinolaryngology

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