Detection of elevated serum β-chemokine levels in seronegative Chinese individuals exposed to human immunodeficiency virus type 1

Biehuoy Shieh, Yao Pei Yan, Nai Ying Ko, Yun Er Liau, Yung Ching Liu, Hsi Hsun Lin, Pei Pei Chen, Ching Li

Research output: Contribution to journalArticle

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Abstract

The mutations in the CCR5 coding region, such as CCR5Δ32 and CCR5m303, that suppress the transmission of human immunodeficiency virus (HIV) type 1 do not exist in Chinese people. However, 9 Chinese subjects in Taiwan with histories of multiple sexual exposures to HIV remained uninfected, suggesting that certain anti-HIV factors do indeed exist. Experiments were therefore designed to investigate the immune mechanism that protects this cohort against HIV infection. Peripheral blood samples from these 9 subjects and 7 healthy people who had not been exposed to HIV were obtained for the quantitation of the levels for β-chemokines and interleukin 16 (IL-16) in serum samples or secreted by peripheral blood lymphocytes. Significantly higher serum levels for nearly all 3 β-chemokines, regulation on activation, normal T cell-expressed and secreted, macrophage inflammatory protein (MIP)-1β, and MIP-1β (P < .05, P < .05, and P = .05, respectively), but not IL-16, were detected in the 9 HIV-uninfected subjects as compared with control subjects. The result suggests that among the host genes and cellular factors thus far identified, β-chemokines are the major HIV-suppressive factors that protect Chinese people from infection with HIV.

Original languageEnglish
Pages (from-to)273-279
Number of pages7
JournalClinical Infectious Diseases
Volume33
Issue number3
DOIs
Publication statusPublished - Aug 1 2001
Externally publishedYes

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Chemokines
HIV-1
HIV
Serum
Interleukin-16
Macrophage Inflammatory Proteins
Virus Diseases
Taiwan
Healthy Volunteers
Lymphocytes
T-Lymphocytes
Mutation
Infection
Genes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Detection of elevated serum β-chemokine levels in seronegative Chinese individuals exposed to human immunodeficiency virus type 1. / Shieh, Biehuoy; Yan, Yao Pei; Ko, Nai Ying; Liau, Yun Er; Liu, Yung Ching; Lin, Hsi Hsun; Chen, Pei Pei; Li, Ching.

In: Clinical Infectious Diseases, Vol. 33, No. 3, 01.08.2001, p. 273-279.

Research output: Contribution to journalArticle

Shieh, Biehuoy ; Yan, Yao Pei ; Ko, Nai Ying ; Liau, Yun Er ; Liu, Yung Ching ; Lin, Hsi Hsun ; Chen, Pei Pei ; Li, Ching. / Detection of elevated serum β-chemokine levels in seronegative Chinese individuals exposed to human immunodeficiency virus type 1. In: Clinical Infectious Diseases. 2001 ; Vol. 33, No. 3. pp. 273-279.
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