Detection and characterization of traumatic bile leaks using Gd-EOB-DTPA enhanced magnetic resonance cholangiography

Yon Cheong Wong, Li Jen Wang, Cheng Hsien Wu, Huan Wu Chen, Chen Ju Fu, Kuo Ching Yuan, Being Chuan Lin, Yu Pao Hsu, Shih Ching Kang

Research output: Contribution to journalArticle

Abstract

Expanding bile leaks after blunt liver trauma require more aggressive treatment than contained bile leaks. In this retrospective study approved by institution review board, we analyzed if non-invasive contrast-enhanced magnetic resonance cholangiography (CEMRC) using hepatocyte-specific contrast agent (gadoxetic acid disodium) could detect and characterize traumatic bile leaks. Between March 2012 and December 2014, written informed consents from 22 included patients (17 men, 5 women) with a median age of 24.5 years (IQR 21.8, 36.0 years) were obtained. Biliary tree visualization and bile leak detection on CEMRC acquired at 10, 20, 30, 90 minutes time points were independently graded by three radiologists on a 5-point Likert scale. Intraclass Correlation (ICC) was computed as estimates of interrater reliability. Accuracy was measured by area under receiver operating characteristic curves (AUROC). Biliary tree visualization was the best on CEMRC at 90 minutes (score 4.30) with excellent inter-rater reliability (ICC = 0.930). Of 22 CEMRC, 15 had bile leak (8 expanding, 7 contained). The largest AUROC of bile leak detection by three radiologists were 0.824, 0.914, 0.929 respectively on CEMRC at 90 minutes with ICC of 0.816. In conclusion, bile leaks of blunt liver trauma can be accurately detected and characterized on CEMRC.

Original languageEnglish
Article number14612
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - Dec 1 2018
Externally publishedYes

Fingerprint

Cholangiography
Bile
Magnetic Resonance Spectroscopy
Biliary Tract
ROC Curve
Liver
Wounds and Injuries
gadolinium ethoxybenzyl DTPA
Informed Consent
Contrast Media
Hepatocytes
Retrospective Studies

ASJC Scopus subject areas

  • General

Cite this

Detection and characterization of traumatic bile leaks using Gd-EOB-DTPA enhanced magnetic resonance cholangiography. / Wong, Yon Cheong; Wang, Li Jen; Wu, Cheng Hsien; Chen, Huan Wu; Fu, Chen Ju; Yuan, Kuo Ching; Lin, Being Chuan; Hsu, Yu Pao; Kang, Shih Ching.

In: Scientific Reports, Vol. 8, No. 1, 14612, 01.12.2018.

Research output: Contribution to journalArticle

Wong, Yon Cheong ; Wang, Li Jen ; Wu, Cheng Hsien ; Chen, Huan Wu ; Fu, Chen Ju ; Yuan, Kuo Ching ; Lin, Being Chuan ; Hsu, Yu Pao ; Kang, Shih Ching. / Detection and characterization of traumatic bile leaks using Gd-EOB-DTPA enhanced magnetic resonance cholangiography. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
@article{d5e4562192814a7bb9986da6ffa7f70e,
title = "Detection and characterization of traumatic bile leaks using Gd-EOB-DTPA enhanced magnetic resonance cholangiography",
abstract = "Expanding bile leaks after blunt liver trauma require more aggressive treatment than contained bile leaks. In this retrospective study approved by institution review board, we analyzed if non-invasive contrast-enhanced magnetic resonance cholangiography (CEMRC) using hepatocyte-specific contrast agent (gadoxetic acid disodium) could detect and characterize traumatic bile leaks. Between March 2012 and December 2014, written informed consents from 22 included patients (17 men, 5 women) with a median age of 24.5 years (IQR 21.8, 36.0 years) were obtained. Biliary tree visualization and bile leak detection on CEMRC acquired at 10, 20, 30, 90 minutes time points were independently graded by three radiologists on a 5-point Likert scale. Intraclass Correlation (ICC) was computed as estimates of interrater reliability. Accuracy was measured by area under receiver operating characteristic curves (AUROC). Biliary tree visualization was the best on CEMRC at 90 minutes (score 4.30) with excellent inter-rater reliability (ICC = 0.930). Of 22 CEMRC, 15 had bile leak (8 expanding, 7 contained). The largest AUROC of bile leak detection by three radiologists were 0.824, 0.914, 0.929 respectively on CEMRC at 90 minutes with ICC of 0.816. In conclusion, bile leaks of blunt liver trauma can be accurately detected and characterized on CEMRC.",
author = "Wong, {Yon Cheong} and Wang, {Li Jen} and Wu, {Cheng Hsien} and Chen, {Huan Wu} and Fu, {Chen Ju} and Yuan, {Kuo Ching} and Lin, {Being Chuan} and Hsu, {Yu Pao} and Kang, {Shih Ching}",
year = "2018",
month = "12",
day = "1",
doi = "10.1038/s41598-018-32976-0",
language = "English",
volume = "8",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Detection and characterization of traumatic bile leaks using Gd-EOB-DTPA enhanced magnetic resonance cholangiography

AU - Wong, Yon Cheong

AU - Wang, Li Jen

AU - Wu, Cheng Hsien

AU - Chen, Huan Wu

AU - Fu, Chen Ju

AU - Yuan, Kuo Ching

AU - Lin, Being Chuan

AU - Hsu, Yu Pao

AU - Kang, Shih Ching

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Expanding bile leaks after blunt liver trauma require more aggressive treatment than contained bile leaks. In this retrospective study approved by institution review board, we analyzed if non-invasive contrast-enhanced magnetic resonance cholangiography (CEMRC) using hepatocyte-specific contrast agent (gadoxetic acid disodium) could detect and characterize traumatic bile leaks. Between March 2012 and December 2014, written informed consents from 22 included patients (17 men, 5 women) with a median age of 24.5 years (IQR 21.8, 36.0 years) were obtained. Biliary tree visualization and bile leak detection on CEMRC acquired at 10, 20, 30, 90 minutes time points were independently graded by three radiologists on a 5-point Likert scale. Intraclass Correlation (ICC) was computed as estimates of interrater reliability. Accuracy was measured by area under receiver operating characteristic curves (AUROC). Biliary tree visualization was the best on CEMRC at 90 minutes (score 4.30) with excellent inter-rater reliability (ICC = 0.930). Of 22 CEMRC, 15 had bile leak (8 expanding, 7 contained). The largest AUROC of bile leak detection by three radiologists were 0.824, 0.914, 0.929 respectively on CEMRC at 90 minutes with ICC of 0.816. In conclusion, bile leaks of blunt liver trauma can be accurately detected and characterized on CEMRC.

AB - Expanding bile leaks after blunt liver trauma require more aggressive treatment than contained bile leaks. In this retrospective study approved by institution review board, we analyzed if non-invasive contrast-enhanced magnetic resonance cholangiography (CEMRC) using hepatocyte-specific contrast agent (gadoxetic acid disodium) could detect and characterize traumatic bile leaks. Between March 2012 and December 2014, written informed consents from 22 included patients (17 men, 5 women) with a median age of 24.5 years (IQR 21.8, 36.0 years) were obtained. Biliary tree visualization and bile leak detection on CEMRC acquired at 10, 20, 30, 90 minutes time points were independently graded by three radiologists on a 5-point Likert scale. Intraclass Correlation (ICC) was computed as estimates of interrater reliability. Accuracy was measured by area under receiver operating characteristic curves (AUROC). Biliary tree visualization was the best on CEMRC at 90 minutes (score 4.30) with excellent inter-rater reliability (ICC = 0.930). Of 22 CEMRC, 15 had bile leak (8 expanding, 7 contained). The largest AUROC of bile leak detection by three radiologists were 0.824, 0.914, 0.929 respectively on CEMRC at 90 minutes with ICC of 0.816. In conclusion, bile leaks of blunt liver trauma can be accurately detected and characterized on CEMRC.

UR - http://www.scopus.com/inward/record.url?scp=85054177884&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054177884&partnerID=8YFLogxK

U2 - 10.1038/s41598-018-32976-0

DO - 10.1038/s41598-018-32976-0

M3 - Article

C2 - 30279434

AN - SCOPUS:85054177884

VL - 8

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 14612

ER -