Design, synthesis and evaluation of arylidene pyrrolo and pyrido fused quinazolones as antimicrobial agents

Kunal Nepali, Ritu Ojha, Aninder Singh, Abhishek Budhiraja, Preet Mohinder Singh Bedi, Kanaya Lal Dhar

Research output: Contribution to journalArticle

Abstract

Keeping in view the potential of heterocyclic fused quinazolones and arylidene linked heterocycles , hybrid molecules of these functionalities were designed and synthesised. All the synthesised molecules were characterized by spectroscopic techniques and evaluated for antimicrobial activity against 2 Gram positive bacterial strains; Staphylococcus aureus (MTCC 96) and Bacillus subtilis (MTCC 2451), 3 Gram negative bacterial strains; Escherichia coli (MTCC 82), Pseudomonas aeruginosa (MTCC 2642) and Salmonella typhimurium (MTCC 1251) and 2 fungal strains; Saccharomyces cerevisiae (MTCC 2799) and Candida albicans (MTCC 3018). Among the synthesised molecules, arylidene pyrrolo fused quinazolones displayed significant antimicrobial activity in comparison to arylidene pyrido fused quinazolones. The influence of the electronic factors linked with the arylidene ring was also observed on the antimicrobial potential. Thus the present study highlights the potential of such hybrid molecules as a new class of antimicrobials.

Original languageEnglish
Pages (from-to)522-528
Number of pages7
JournalLetters in Drug Design and Discovery
Volume10
Issue number6
DOIs
Publication statusPublished - Jul 1 2013
Externally publishedYes

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Salmonella typhimurium
Anti-Infective Agents
Bacillus subtilis
Candida albicans
Pseudomonas aeruginosa
Saccharomyces cerevisiae
Staphylococcus aureus
Escherichia coli

Keywords

  • Antimicrobial
  • Pyrido
  • Pyrrolo
  • Quinazoline
  • Strains

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

Cite this

Design, synthesis and evaluation of arylidene pyrrolo and pyrido fused quinazolones as antimicrobial agents. / Nepali, Kunal; Ojha, Ritu; Singh, Aninder; Budhiraja, Abhishek; Bedi, Preet Mohinder Singh; Dhar, Kanaya Lal.

In: Letters in Drug Design and Discovery, Vol. 10, No. 6, 01.07.2013, p. 522-528.

Research output: Contribution to journalArticle

Nepali, Kunal ; Ojha, Ritu ; Singh, Aninder ; Budhiraja, Abhishek ; Bedi, Preet Mohinder Singh ; Dhar, Kanaya Lal. / Design, synthesis and evaluation of arylidene pyrrolo and pyrido fused quinazolones as antimicrobial agents. In: Letters in Drug Design and Discovery. 2013 ; Vol. 10, No. 6. pp. 522-528.
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