Design of a 0.5 v 1.68mW nose-on-a-chip for rapid screen of chronic obstructive pulmonary disease

Ting I. Chou, Shih Wen Chiu, Kwuang Han Chang, Yi Ju Chen, Chen Ting Tang, Chung Hung Shih, Chih Cheng Hsieh, Meng Fan Chang, Chia Hsiang Yang, Herming Chiueh, Kea Tiong Tang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Chronic obstructive pulmonary disease (COPD) still lacks a rapid diagnosis strategy. In this paper, we propose a low-power nose-on-a-chip for rapid COPD screening. This chip is designed for implementation in a personal handheld device that detects patient breath for COPD diagnosis. The chip has 36 on-chip sensors, a 36-channel adaptive interface with an integrated programmable amplifier, a four-channel frequency readout interface, one on-chip temperature sensor, a two-channel successive approximation analog-to-digital converter, a scalable learning kernel cluster, and a reduced instruction set computing core with low-voltage static random-access memory. This chip is fabricated in 90 nm CMOS and consumes 1.68 mW at 0.5 V. In simulation, the system distinguished between undiseased and diseased patients with 90.82% accuracy for a set of diseases including COPD and asthma and exhibited 92.31% accuracy for identifying patients with COPD or asthma. The system classified severity levels of COPD under four labels (normal, mild, moderate, and severe) with 92.00% accuracy. Accordingly, this work provides a promising solution for the unmet medical need of rapid COPD screening.

Original languageEnglish
Title of host publicationProceedings - 2016 IEEE Biomedical Circuits and Systems Conference, BioCAS 2016
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages592-595
Number of pages4
ISBN (Electronic)9781509029594
DOIs
Publication statusPublished - 2016
Event12th IEEE Biomedical Circuits and Systems Conference, BioCAS 2016 - Shanghai, China
Duration: Oct 17 2016Oct 19 2016

Other

Other12th IEEE Biomedical Circuits and Systems Conference, BioCAS 2016
CountryChina
CityShanghai
Period10/17/1610/19/16

Fingerprint

Pulmonary diseases
chips
asthma
Screening
RISC processors
screening
Reduced instruction set computing
Temperature sensors
Digital to analog conversion
random access memory
analog to digital converters
temperature sensors
Labels
low voltage
learning
readout
CMOS
amplifiers
Data storage equipment
Sensors

Keywords

  • COPD
  • Nose-on-a-chip system
  • SoC

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Instrumentation
  • Biomedical Engineering

Cite this

Chou, T. I., Chiu, S. W., Chang, K. H., Chen, Y. J., Tang, C. T., Shih, C. H., ... Tang, K. T. (2016). Design of a 0.5 v 1.68mW nose-on-a-chip for rapid screen of chronic obstructive pulmonary disease. In Proceedings - 2016 IEEE Biomedical Circuits and Systems Conference, BioCAS 2016 (pp. 592-595). [7833864] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BioCAS.2016.7833864

Design of a 0.5 v 1.68mW nose-on-a-chip for rapid screen of chronic obstructive pulmonary disease. / Chou, Ting I.; Chiu, Shih Wen; Chang, Kwuang Han; Chen, Yi Ju; Tang, Chen Ting; Shih, Chung Hung; Hsieh, Chih Cheng; Chang, Meng Fan; Yang, Chia Hsiang; Chiueh, Herming; Tang, Kea Tiong.

Proceedings - 2016 IEEE Biomedical Circuits and Systems Conference, BioCAS 2016. Institute of Electrical and Electronics Engineers Inc., 2016. p. 592-595 7833864.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Chou, TI, Chiu, SW, Chang, KH, Chen, YJ, Tang, CT, Shih, CH, Hsieh, CC, Chang, MF, Yang, CH, Chiueh, H & Tang, KT 2016, Design of a 0.5 v 1.68mW nose-on-a-chip for rapid screen of chronic obstructive pulmonary disease. in Proceedings - 2016 IEEE Biomedical Circuits and Systems Conference, BioCAS 2016., 7833864, Institute of Electrical and Electronics Engineers Inc., pp. 592-595, 12th IEEE Biomedical Circuits and Systems Conference, BioCAS 2016, Shanghai, China, 10/17/16. https://doi.org/10.1109/BioCAS.2016.7833864
Chou TI, Chiu SW, Chang KH, Chen YJ, Tang CT, Shih CH et al. Design of a 0.5 v 1.68mW nose-on-a-chip for rapid screen of chronic obstructive pulmonary disease. In Proceedings - 2016 IEEE Biomedical Circuits and Systems Conference, BioCAS 2016. Institute of Electrical and Electronics Engineers Inc. 2016. p. 592-595. 7833864 https://doi.org/10.1109/BioCAS.2016.7833864
Chou, Ting I. ; Chiu, Shih Wen ; Chang, Kwuang Han ; Chen, Yi Ju ; Tang, Chen Ting ; Shih, Chung Hung ; Hsieh, Chih Cheng ; Chang, Meng Fan ; Yang, Chia Hsiang ; Chiueh, Herming ; Tang, Kea Tiong. / Design of a 0.5 v 1.68mW nose-on-a-chip for rapid screen of chronic obstructive pulmonary disease. Proceedings - 2016 IEEE Biomedical Circuits and Systems Conference, BioCAS 2016. Institute of Electrical and Electronics Engineers Inc., 2016. pp. 592-595
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