Depression as the primary cause of insomnia and excessive daytime sleepiness in a family with multiple cases of spinocerebellar ataxia

Chun Hsien Hsu, Yen Lin Chen, Dee Pei, Shu Man Yu, I. Chao Liu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Spinocerebellar ataxia (SCA) is a hereditary disease characterized by central nervous system-related motor dysfunctions. Sleep disorders and frequent non-motor manifestations are commonly comorbid with SCA. To elucidate this relationship, we present three cases in a family that included multiple SCA type 2 patients with various sleep disorders. Complete physical examination, and genetic and imaging studies were performed. Anti-parkinsonism medications were prescribed after neurological examination. Clonazepam and/or quetiapine were administered for sleep disorders but failed to resolve insomnia and excessive daytime sleepiness (EDS). Based on DSM-5 criteria, all cases were diagnosed with depression. After treatment with serotonin-norepinephrine reuptake inhibitors and noradrenergic and specific serotonergic antidepressants, symptoms of insomnia and EDS, which are strongly associated with depression in SCA type 2 patients, improved significantly. It is crucial to recognize insomnia and EDS in neurodegenerative diseases, not only for earlier diagnosis, but also to improve quality of life.

Original languageEnglish
Pages (from-to)1059-1061
Number of pages3
JournalJournal of Clinical Sleep Medicine
Volume12
Issue number7
DOIs
Publication statusPublished - 2016

Fingerprint

Spinocerebellar Ataxias
Sleep Initiation and Maintenance Disorders
Depression
Clonazepam
Inborn Genetic Diseases
Neurologic Examination
Parkinsonian Disorders
Neurodegenerative Diseases
Antidepressive Agents
Physical Examination
Early Diagnosis
Central Nervous System
Quality of Life
Sleep Wake Disorders

Keywords

  • Depression
  • Excessive daytime sleepiness
  • Insomnia
  • Sleep disorders
  • Spinocerebellar ataxia

ASJC Scopus subject areas

  • Clinical Neurology
  • Pulmonary and Respiratory Medicine
  • Neurology

Cite this

Depression as the primary cause of insomnia and excessive daytime sleepiness in a family with multiple cases of spinocerebellar ataxia. / Hsu, Chun Hsien; Chen, Yen Lin; Pei, Dee; Yu, Shu Man; Liu, I. Chao.

In: Journal of Clinical Sleep Medicine, Vol. 12, No. 7, 2016, p. 1059-1061.

Research output: Contribution to journalArticle

Hsu, Chun Hsien ; Chen, Yen Lin ; Pei, Dee ; Yu, Shu Man ; Liu, I. Chao. / Depression as the primary cause of insomnia and excessive daytime sleepiness in a family with multiple cases of spinocerebellar ataxia. In: Journal of Clinical Sleep Medicine. 2016 ; Vol. 12, No. 7. pp. 1059-1061.
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