Depression and cholesteatoma

Preliminary findings from a nationwide population-based retrospective cohort study

Chin Lung Kuo, Nancy Hsaoyen Chang, An Suey Shiao, Chiang Feng Lien, Hsiao Ling Huang, Szu Hai Lin, Wei Pin Chang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective To estimate the risk of developing depressive disorder (DD) following diagnosis with cholesteatoma. Methods In the study, we analyzed data from the Longitudinal Health Insurance Database of Taiwan. A total of 599 patients newly diagnosed with cholesteatoma between 1997 and 2007 were included with a comparison cohort of 2995 matched non-cholesteatoma enrollees. Each patient was followed for 3 years to identify the subsequent development of DD. Cox proportional hazard regression analysis was performed to compute adjusted 3-year hazard ratios. Results The incidence of DD per thousand person-years was approximately twice as high among patients with cholesteatoma (11.32) as among those without cholesteatoma (5.85). After adjusting for potential confounders, patients with cholesteatoma were 1.99 times (95% CI=1.18-3.34, P=0.010) more likely to suffer from DD within 3 years compared to those without cholesteatoma. Conclusions This is the first study to demonstrate a link between cholesteatoma and subsequent DD within a three-year followup. We suggest that clinicians keep this critical but neglected issue in mind and carefully investigate the possibility of subsequent psychological problems among cholesteatoma patients.

Original languageEnglish
Pages (from-to)222-225
Number of pages4
JournalJournal of Affective Disorders
Volume194
DOIs
Publication statusPublished - Apr 1 2016

Fingerprint

Cholesteatoma
Cohort Studies
Retrospective Studies
Depression
Depressive Disorder
Population
Health Insurance
Taiwan
Regression Analysis
Databases
Psychology
Incidence

Keywords

  • Cholesteatoma
  • Depression
  • Population-based study

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Depression and cholesteatoma : Preliminary findings from a nationwide population-based retrospective cohort study. / Kuo, Chin Lung; Hsaoyen Chang, Nancy; Shiao, An Suey; Lien, Chiang Feng; Huang, Hsiao Ling; Lin, Szu Hai; Chang, Wei Pin.

In: Journal of Affective Disorders, Vol. 194, 01.04.2016, p. 222-225.

Research output: Contribution to journalArticle

Kuo, Chin Lung ; Hsaoyen Chang, Nancy ; Shiao, An Suey ; Lien, Chiang Feng ; Huang, Hsiao Ling ; Lin, Szu Hai ; Chang, Wei Pin. / Depression and cholesteatoma : Preliminary findings from a nationwide population-based retrospective cohort study. In: Journal of Affective Disorders. 2016 ; Vol. 194. pp. 222-225.
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