Demographic characteristic of ankylosing spondylitis in Chinese

Chun Hsiung Chen, Hung An Chen, Hsien Tzung Liao, Chin Hsiu Liu, Toong Hua Liang, Chang Youh Tsai, Chung Tei Chou

Research output: Contribution to journalArticle

Abstract

Objective: To investigate the demographic characteristic of ankylosing spondylitis (AS) in Chinese. Methods: Three hundred sixty Chinese AS patients in Taiwan were enrolled in this study. These AS patients fulfilled the 1984 modified New York criteria and visited the Outpatient Department of Veterans General Hospital-Taipei. Patients completed the questionnaires, containing disease activity (BASDAI), functional ability (BASFI) and patient's global assessment (BAS-G). Physical examinations were performed to determine the spinal mobility, including modified Schober index (MSI), fingertip-to-floor distance (FFD), lumbar lateral flexion (LLF), and occiput-to-wall distance (OWD) and chest expansion (CE). Results: The mean (S.D) onset age of the 360 AS patients was 23.79 (9.15) y/o and the male-to-female ratio 3.68 (283/77). The HLA B27 positive rate of the AS patients was 91% (328/360). The ratio of the 360 AS patients with history of peripheral joint involvement was 60.3% (217/360), and the ratio of the 360 AS patients with uveitis was 10% (36/360). The mean (S.D) score of the BASDAI, BASFI, and BASG were 4.19 (2.07), 2.69 (2.37), and 5.05 (2.82), respectively. Significant decrease MSI [3.78 (2.21) vs. 4.97 (2.87) cm, p = 0.001] and increased FFD [22.64 (16.36) vs. 16.81 (14.28) cm, p = 0.002] were observed in the male than in the female AS patients. BASDAI [4.72 (2.03) vs. 3.39 (1.87), p <0.001], BASFI [3.21 (2.51) vs. 1.91 (1.89), p <0.001], BASG [5.62 (2.81) vs. 4.19 (2.63), p <0.001] were significantly higher in the AS patients with history of peripheral joint involvement than those without. BASDAI [4.92 (2.21) vs. 4.11 (2.04), p = 0.011] was significantly higher in the AS patients with history of uveitis than those without. BASDAI showed mild correlation with MSI (r = -0.122, p = 0.021), FFD (r = 0.186, p <0.001) and CE (r = -0.104, p = 0.049). BASFI showed high correlation with FFD (r = 0.485, p <0.001), and OWD (r = 0.412, p <0.001), and moderate correlation with MSI (r = -0.365, p <0.001), CE (r = -0.285, p <0.001) and LLF (r = 0.249, p <0.001). Conclusion: The Chinese AS patients in Taiwan predominantly affected young male adult. More severe spinal limitation was found in the male AS patients. Higher disease activity and poor functional ability were observed in the AS patients with history of peripheral joint involvement. The AS patients with uveitis have higher disease activity. Limitation of spinal flexion could be a useful index of functional impairment.

Original languageEnglish
Pages (from-to)177-181
Number of pages5
JournalCurrent Rheumatology Reviews
Volume5
Issue number3
DOIs
Publication statusPublished - Aug 2009

Fingerprint

Ankylosing Spondylitis
Demography
Uveitis
Joints
Taiwan
Thorax
Veterans Hospitals
HLA-B27 Antigen
Thoracic Wall
Age of Onset
General Hospitals
Physical Examination
Young Adult

Keywords

  • Ankylosing spondylitis
  • BASDAI
  • BASFI
  • Chinese
  • Demographic
  • Peripheral arthritis
  • Uveitis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Chen, C. H., Chen, H. A., Liao, H. T., Liu, C. H., Liang, T. H., Tsai, C. Y., & Chou, C. T. (2009). Demographic characteristic of ankylosing spondylitis in Chinese. Current Rheumatology Reviews, 5(3), 177-181. https://doi.org/10.2174/157339709789208697

Demographic characteristic of ankylosing spondylitis in Chinese. / Chen, Chun Hsiung; Chen, Hung An; Liao, Hsien Tzung; Liu, Chin Hsiu; Liang, Toong Hua; Tsai, Chang Youh; Chou, Chung Tei.

In: Current Rheumatology Reviews, Vol. 5, No. 3, 08.2009, p. 177-181.

Research output: Contribution to journalArticle

Chen, CH, Chen, HA, Liao, HT, Liu, CH, Liang, TH, Tsai, CY & Chou, CT 2009, 'Demographic characteristic of ankylosing spondylitis in Chinese', Current Rheumatology Reviews, vol. 5, no. 3, pp. 177-181. https://doi.org/10.2174/157339709789208697
Chen, Chun Hsiung ; Chen, Hung An ; Liao, Hsien Tzung ; Liu, Chin Hsiu ; Liang, Toong Hua ; Tsai, Chang Youh ; Chou, Chung Tei. / Demographic characteristic of ankylosing spondylitis in Chinese. In: Current Rheumatology Reviews. 2009 ; Vol. 5, No. 3. pp. 177-181.
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abstract = "Objective: To investigate the demographic characteristic of ankylosing spondylitis (AS) in Chinese. Methods: Three hundred sixty Chinese AS patients in Taiwan were enrolled in this study. These AS patients fulfilled the 1984 modified New York criteria and visited the Outpatient Department of Veterans General Hospital-Taipei. Patients completed the questionnaires, containing disease activity (BASDAI), functional ability (BASFI) and patient's global assessment (BAS-G). Physical examinations were performed to determine the spinal mobility, including modified Schober index (MSI), fingertip-to-floor distance (FFD), lumbar lateral flexion (LLF), and occiput-to-wall distance (OWD) and chest expansion (CE). Results: The mean (S.D) onset age of the 360 AS patients was 23.79 (9.15) y/o and the male-to-female ratio 3.68 (283/77). The HLA B27 positive rate of the AS patients was 91{\%} (328/360). The ratio of the 360 AS patients with history of peripheral joint involvement was 60.3{\%} (217/360), and the ratio of the 360 AS patients with uveitis was 10{\%} (36/360). The mean (S.D) score of the BASDAI, BASFI, and BASG were 4.19 (2.07), 2.69 (2.37), and 5.05 (2.82), respectively. Significant decrease MSI [3.78 (2.21) vs. 4.97 (2.87) cm, p = 0.001] and increased FFD [22.64 (16.36) vs. 16.81 (14.28) cm, p = 0.002] were observed in the male than in the female AS patients. BASDAI [4.72 (2.03) vs. 3.39 (1.87), p <0.001], BASFI [3.21 (2.51) vs. 1.91 (1.89), p <0.001], BASG [5.62 (2.81) vs. 4.19 (2.63), p <0.001] were significantly higher in the AS patients with history of peripheral joint involvement than those without. BASDAI [4.92 (2.21) vs. 4.11 (2.04), p = 0.011] was significantly higher in the AS patients with history of uveitis than those without. BASDAI showed mild correlation with MSI (r = -0.122, p = 0.021), FFD (r = 0.186, p <0.001) and CE (r = -0.104, p = 0.049). BASFI showed high correlation with FFD (r = 0.485, p <0.001), and OWD (r = 0.412, p <0.001), and moderate correlation with MSI (r = -0.365, p <0.001), CE (r = -0.285, p <0.001) and LLF (r = 0.249, p <0.001). Conclusion: The Chinese AS patients in Taiwan predominantly affected young male adult. More severe spinal limitation was found in the male AS patients. Higher disease activity and poor functional ability were observed in the AS patients with history of peripheral joint involvement. The AS patients with uveitis have higher disease activity. Limitation of spinal flexion could be a useful index of functional impairment.",
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author = "Chen, {Chun Hsiung} and Chen, {Hung An} and Liao, {Hsien Tzung} and Liu, {Chin Hsiu} and Liang, {Toong Hua} and Tsai, {Chang Youh} and Chou, {Chung Tei}",
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T1 - Demographic characteristic of ankylosing spondylitis in Chinese

AU - Chen, Chun Hsiung

AU - Chen, Hung An

AU - Liao, Hsien Tzung

AU - Liu, Chin Hsiu

AU - Liang, Toong Hua

AU - Tsai, Chang Youh

AU - Chou, Chung Tei

PY - 2009/8

Y1 - 2009/8

N2 - Objective: To investigate the demographic characteristic of ankylosing spondylitis (AS) in Chinese. Methods: Three hundred sixty Chinese AS patients in Taiwan were enrolled in this study. These AS patients fulfilled the 1984 modified New York criteria and visited the Outpatient Department of Veterans General Hospital-Taipei. Patients completed the questionnaires, containing disease activity (BASDAI), functional ability (BASFI) and patient's global assessment (BAS-G). Physical examinations were performed to determine the spinal mobility, including modified Schober index (MSI), fingertip-to-floor distance (FFD), lumbar lateral flexion (LLF), and occiput-to-wall distance (OWD) and chest expansion (CE). Results: The mean (S.D) onset age of the 360 AS patients was 23.79 (9.15) y/o and the male-to-female ratio 3.68 (283/77). The HLA B27 positive rate of the AS patients was 91% (328/360). The ratio of the 360 AS patients with history of peripheral joint involvement was 60.3% (217/360), and the ratio of the 360 AS patients with uveitis was 10% (36/360). The mean (S.D) score of the BASDAI, BASFI, and BASG were 4.19 (2.07), 2.69 (2.37), and 5.05 (2.82), respectively. Significant decrease MSI [3.78 (2.21) vs. 4.97 (2.87) cm, p = 0.001] and increased FFD [22.64 (16.36) vs. 16.81 (14.28) cm, p = 0.002] were observed in the male than in the female AS patients. BASDAI [4.72 (2.03) vs. 3.39 (1.87), p <0.001], BASFI [3.21 (2.51) vs. 1.91 (1.89), p <0.001], BASG [5.62 (2.81) vs. 4.19 (2.63), p <0.001] were significantly higher in the AS patients with history of peripheral joint involvement than those without. BASDAI [4.92 (2.21) vs. 4.11 (2.04), p = 0.011] was significantly higher in the AS patients with history of uveitis than those without. BASDAI showed mild correlation with MSI (r = -0.122, p = 0.021), FFD (r = 0.186, p <0.001) and CE (r = -0.104, p = 0.049). BASFI showed high correlation with FFD (r = 0.485, p <0.001), and OWD (r = 0.412, p <0.001), and moderate correlation with MSI (r = -0.365, p <0.001), CE (r = -0.285, p <0.001) and LLF (r = 0.249, p <0.001). Conclusion: The Chinese AS patients in Taiwan predominantly affected young male adult. More severe spinal limitation was found in the male AS patients. Higher disease activity and poor functional ability were observed in the AS patients with history of peripheral joint involvement. The AS patients with uveitis have higher disease activity. Limitation of spinal flexion could be a useful index of functional impairment.

AB - Objective: To investigate the demographic characteristic of ankylosing spondylitis (AS) in Chinese. Methods: Three hundred sixty Chinese AS patients in Taiwan were enrolled in this study. These AS patients fulfilled the 1984 modified New York criteria and visited the Outpatient Department of Veterans General Hospital-Taipei. Patients completed the questionnaires, containing disease activity (BASDAI), functional ability (BASFI) and patient's global assessment (BAS-G). Physical examinations were performed to determine the spinal mobility, including modified Schober index (MSI), fingertip-to-floor distance (FFD), lumbar lateral flexion (LLF), and occiput-to-wall distance (OWD) and chest expansion (CE). Results: The mean (S.D) onset age of the 360 AS patients was 23.79 (9.15) y/o and the male-to-female ratio 3.68 (283/77). The HLA B27 positive rate of the AS patients was 91% (328/360). The ratio of the 360 AS patients with history of peripheral joint involvement was 60.3% (217/360), and the ratio of the 360 AS patients with uveitis was 10% (36/360). The mean (S.D) score of the BASDAI, BASFI, and BASG were 4.19 (2.07), 2.69 (2.37), and 5.05 (2.82), respectively. Significant decrease MSI [3.78 (2.21) vs. 4.97 (2.87) cm, p = 0.001] and increased FFD [22.64 (16.36) vs. 16.81 (14.28) cm, p = 0.002] were observed in the male than in the female AS patients. BASDAI [4.72 (2.03) vs. 3.39 (1.87), p <0.001], BASFI [3.21 (2.51) vs. 1.91 (1.89), p <0.001], BASG [5.62 (2.81) vs. 4.19 (2.63), p <0.001] were significantly higher in the AS patients with history of peripheral joint involvement than those without. BASDAI [4.92 (2.21) vs. 4.11 (2.04), p = 0.011] was significantly higher in the AS patients with history of uveitis than those without. BASDAI showed mild correlation with MSI (r = -0.122, p = 0.021), FFD (r = 0.186, p <0.001) and CE (r = -0.104, p = 0.049). BASFI showed high correlation with FFD (r = 0.485, p <0.001), and OWD (r = 0.412, p <0.001), and moderate correlation with MSI (r = -0.365, p <0.001), CE (r = -0.285, p <0.001) and LLF (r = 0.249, p <0.001). Conclusion: The Chinese AS patients in Taiwan predominantly affected young male adult. More severe spinal limitation was found in the male AS patients. Higher disease activity and poor functional ability were observed in the AS patients with history of peripheral joint involvement. The AS patients with uveitis have higher disease activity. Limitation of spinal flexion could be a useful index of functional impairment.

KW - Ankylosing spondylitis

KW - BASDAI

KW - BASFI

KW - Chinese

KW - Demographic

KW - Peripheral arthritis

KW - Uveitis

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