Abstract

Background: Cardiovascular diseases are reported to be associated with both chronic rhinosinusitis (CRS) and dementia. Nevertheless, whether dementia is associated with CRS is still unknown. In the present study, we explored the association between dementia with prior CRS using a population-based data set. Methods: This study used the Taiwan Longitudinal Health Insurance Database 2000 as the source of data for a case- control study. We included 8768 subjects with dementia as cases and 8768 age- and sex-matched subjects as controls. We identified cases who had received a diagnosis of CRS before having received a diagnosis of dementia. Conditional logistic regression analyses were performed to examine the association of dementia with previously diagnosed CRS. Results: Results showed that of all sampled subjects, 875 (5.0%) had been previously diagnosed with CRS. A chi-squared test showed that there was a significant difference in the prevalences of prior CRS between cases and controls (6.0% versus 4.0%; p <0.001). The adjusted odds ratio (OR) of prior CRS for subjects with dementia was 1.44 (95% CI, 1.25~1.66) compared with controls. Furthermore, compared with controls, the OR of prior CRS was similar for subjects with dementia for both sexes (the OR for male subjects was 1.48 and OR for female subjects was 1.41). Conclusion: We concluded that subjects with dementia had a higher odds of having had prior CRS than controls. This study implies a potential association between CRS and dementia.

Original languageEnglish
Pages (from-to)44-47
Number of pages4
JournalAmerican Journal of Rhinology and Allergy
Volume29
Issue number1
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

Dementia
Population
Odds Ratio
Information Storage and Retrieval
Sex Ratio
Health Insurance
Taiwan
Case-Control Studies
Cardiovascular Diseases
Logistic Models
Regression Analysis
Databases

ASJC Scopus subject areas

  • Immunology and Allergy
  • Otorhinolaryngology
  • Medicine(all)

Cite this

@article{bc57504947ff4199a42ee38bbba8a8c6,
title = "Dementia is associated with chronic rhinosinusitis: A population-based case-controlled study",
abstract = "Background: Cardiovascular diseases are reported to be associated with both chronic rhinosinusitis (CRS) and dementia. Nevertheless, whether dementia is associated with CRS is still unknown. In the present study, we explored the association between dementia with prior CRS using a population-based data set. Methods: This study used the Taiwan Longitudinal Health Insurance Database 2000 as the source of data for a case- control study. We included 8768 subjects with dementia as cases and 8768 age- and sex-matched subjects as controls. We identified cases who had received a diagnosis of CRS before having received a diagnosis of dementia. Conditional logistic regression analyses were performed to examine the association of dementia with previously diagnosed CRS. Results: Results showed that of all sampled subjects, 875 (5.0{\%}) had been previously diagnosed with CRS. A chi-squared test showed that there was a significant difference in the prevalences of prior CRS between cases and controls (6.0{\%} versus 4.0{\%}; p <0.001). The adjusted odds ratio (OR) of prior CRS for subjects with dementia was 1.44 (95{\%} CI, 1.25~1.66) compared with controls. Furthermore, compared with controls, the OR of prior CRS was similar for subjects with dementia for both sexes (the OR for male subjects was 1.48 and OR for female subjects was 1.41). Conclusion: We concluded that subjects with dementia had a higher odds of having had prior CRS than controls. This study implies a potential association between CRS and dementia.",
author = "Chung, {Shiu Dong} and Hung, {Shih Han} and Lin, {Herng Ching} and Kang, {Jiunn Horng}",
year = "2015",
month = "1",
day = "1",
doi = "10.2500/ajra.2015.29.4113",
language = "English",
volume = "29",
pages = "44--47",
journal = "American Journal of Rhinology and Allergy",
issn = "1945-8924",
publisher = "OceanSide Publications Inc.",
number = "1",

}

TY - JOUR

T1 - Dementia is associated with chronic rhinosinusitis

T2 - A population-based case-controlled study

AU - Chung, Shiu Dong

AU - Hung, Shih Han

AU - Lin, Herng Ching

AU - Kang, Jiunn Horng

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background: Cardiovascular diseases are reported to be associated with both chronic rhinosinusitis (CRS) and dementia. Nevertheless, whether dementia is associated with CRS is still unknown. In the present study, we explored the association between dementia with prior CRS using a population-based data set. Methods: This study used the Taiwan Longitudinal Health Insurance Database 2000 as the source of data for a case- control study. We included 8768 subjects with dementia as cases and 8768 age- and sex-matched subjects as controls. We identified cases who had received a diagnosis of CRS before having received a diagnosis of dementia. Conditional logistic regression analyses were performed to examine the association of dementia with previously diagnosed CRS. Results: Results showed that of all sampled subjects, 875 (5.0%) had been previously diagnosed with CRS. A chi-squared test showed that there was a significant difference in the prevalences of prior CRS between cases and controls (6.0% versus 4.0%; p <0.001). The adjusted odds ratio (OR) of prior CRS for subjects with dementia was 1.44 (95% CI, 1.25~1.66) compared with controls. Furthermore, compared with controls, the OR of prior CRS was similar for subjects with dementia for both sexes (the OR for male subjects was 1.48 and OR for female subjects was 1.41). Conclusion: We concluded that subjects with dementia had a higher odds of having had prior CRS than controls. This study implies a potential association between CRS and dementia.

AB - Background: Cardiovascular diseases are reported to be associated with both chronic rhinosinusitis (CRS) and dementia. Nevertheless, whether dementia is associated with CRS is still unknown. In the present study, we explored the association between dementia with prior CRS using a population-based data set. Methods: This study used the Taiwan Longitudinal Health Insurance Database 2000 as the source of data for a case- control study. We included 8768 subjects with dementia as cases and 8768 age- and sex-matched subjects as controls. We identified cases who had received a diagnosis of CRS before having received a diagnosis of dementia. Conditional logistic regression analyses were performed to examine the association of dementia with previously diagnosed CRS. Results: Results showed that of all sampled subjects, 875 (5.0%) had been previously diagnosed with CRS. A chi-squared test showed that there was a significant difference in the prevalences of prior CRS between cases and controls (6.0% versus 4.0%; p <0.001). The adjusted odds ratio (OR) of prior CRS for subjects with dementia was 1.44 (95% CI, 1.25~1.66) compared with controls. Furthermore, compared with controls, the OR of prior CRS was similar for subjects with dementia for both sexes (the OR for male subjects was 1.48 and OR for female subjects was 1.41). Conclusion: We concluded that subjects with dementia had a higher odds of having had prior CRS than controls. This study implies a potential association between CRS and dementia.

UR - http://www.scopus.com/inward/record.url?scp=84921057377&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921057377&partnerID=8YFLogxK

U2 - 10.2500/ajra.2015.29.4113

DO - 10.2500/ajra.2015.29.4113

M3 - Article

VL - 29

SP - 44

EP - 47

JO - American Journal of Rhinology and Allergy

JF - American Journal of Rhinology and Allergy

SN - 1945-8924

IS - 1

ER -