Delayed vasal reanastomosis in rats: Comparison of a microsurgical technique and a fibrin-glued procedure

O. Vankemmel, J. M. Rigot, T. Burnouf, E. Mazeman

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objectives: To compare fibrin-glued vasovasostomy to a conventional microsurgical technique in a protocol of delayed vasovasostomy. Materials and methods: Forty male Sprague-Dawley rats underwent bilateral vasectomy through a midline abdominal incision. Two weeks later all animals underwent a bilateral vasectomy reversal through a bilateral inguino-scrotal incision, following two different protocols. Invariably, the proximal segment had a larger lumen. The control group (20 rats) had a conventional modified one- layer sutured vasal anastomosis with 10/0 nylon. The experimental group (20 rats) underwent vasal anastomosis using fibrin glue and consisting of three transmural sutures with 10/0 nylon followed by the application of fibrin glue circumferentially to seal the anastomosis. The fibrin-tissue adhesive was obtained from pooled donor plasma and was virally inactivated by a solvent- detergent treatment. Seven weeks after surgery all animals were killed and the vasal specimens were evaluated for gross patency and the incidence of sperm granuloma. Results: The control group had a patency rate of 85% and half had sperm granuloma. The experimental group had a patency rate of 92% and 40% had sperm granuloma; neither difference was significant. The mean operative time was significantly shorter for the fibrin glue-assisted vasovasostomy (P

Original languageEnglish
Pages (from-to)271-274
Number of pages4
JournalBritish Journal of Urology
Volume78
Issue number2
Publication statusPublished - 1996
Externally publishedYes

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Keywords

  • Fibrin adhesive
  • Microsurgery
  • Vasectomy reversal

ASJC Scopus subject areas

  • Urology

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