Abstract
Objectives: To compare fibrin-glued vasovasostomy to a conventional microsurgical technique in a protocol of delayed vasovasostomy. Materials and methods: Forty male Sprague-Dawley rats underwent bilateral vasectomy through a midline abdominal incision. Two weeks later all animals underwent a bilateral vasectomy reversal through a bilateral inguino-scrotal incision, following two different protocols. Invariably, the proximal segment had a larger lumen. The control group (20 rats) had a conventional modified one- layer sutured vasal anastomosis with 10/0 nylon. The experimental group (20 rats) underwent vasal anastomosis using fibrin glue and consisting of three transmural sutures with 10/0 nylon followed by the application of fibrin glue circumferentially to seal the anastomosis. The fibrin-tissue adhesive was obtained from pooled donor plasma and was virally inactivated by a solvent- detergent treatment. Seven weeks after surgery all animals were killed and the vasal specimens were evaluated for gross patency and the incidence of sperm granuloma. Results: The control group had a patency rate of 85% and half had sperm granuloma. The experimental group had a patency rate of 92% and 40% had sperm granuloma; neither difference was significant. The mean operative time was significantly shorter for the fibrin glue-assisted vasovasostomy (P
| Original language | English |
|---|---|
| Pages (from-to) | 271-274 |
| Number of pages | 4 |
| Journal | British Journal of Urology |
| Volume | 78 |
| Issue number | 2 |
| Publication status | Published - 1996 |
| Externally published | Yes |
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Keywords
- Fibrin adhesive
- Microsurgery
- Vasectomy reversal
ASJC Scopus subject areas
- Urology
Cite this
Delayed vasal reanastomosis in rats : Comparison of a microsurgical technique and a fibrin-glued procedure. / Vankemmel, O.; Rigot, J. M.; Burnouf, T.; Mazeman, E.
In: British Journal of Urology, Vol. 78, No. 2, 1996, p. 271-274.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Delayed vasal reanastomosis in rats
T2 - Comparison of a microsurgical technique and a fibrin-glued procedure
AU - Vankemmel, O.
AU - Rigot, J. M.
AU - Burnouf, T.
AU - Mazeman, E.
PY - 1996
Y1 - 1996
N2 - Objectives: To compare fibrin-glued vasovasostomy to a conventional microsurgical technique in a protocol of delayed vasovasostomy. Materials and methods: Forty male Sprague-Dawley rats underwent bilateral vasectomy through a midline abdominal incision. Two weeks later all animals underwent a bilateral vasectomy reversal through a bilateral inguino-scrotal incision, following two different protocols. Invariably, the proximal segment had a larger lumen. The control group (20 rats) had a conventional modified one- layer sutured vasal anastomosis with 10/0 nylon. The experimental group (20 rats) underwent vasal anastomosis using fibrin glue and consisting of three transmural sutures with 10/0 nylon followed by the application of fibrin glue circumferentially to seal the anastomosis. The fibrin-tissue adhesive was obtained from pooled donor plasma and was virally inactivated by a solvent- detergent treatment. Seven weeks after surgery all animals were killed and the vasal specimens were evaluated for gross patency and the incidence of sperm granuloma. Results: The control group had a patency rate of 85% and half had sperm granuloma. The experimental group had a patency rate of 92% and 40% had sperm granuloma; neither difference was significant. The mean operative time was significantly shorter for the fibrin glue-assisted vasovasostomy (P
AB - Objectives: To compare fibrin-glued vasovasostomy to a conventional microsurgical technique in a protocol of delayed vasovasostomy. Materials and methods: Forty male Sprague-Dawley rats underwent bilateral vasectomy through a midline abdominal incision. Two weeks later all animals underwent a bilateral vasectomy reversal through a bilateral inguino-scrotal incision, following two different protocols. Invariably, the proximal segment had a larger lumen. The control group (20 rats) had a conventional modified one- layer sutured vasal anastomosis with 10/0 nylon. The experimental group (20 rats) underwent vasal anastomosis using fibrin glue and consisting of three transmural sutures with 10/0 nylon followed by the application of fibrin glue circumferentially to seal the anastomosis. The fibrin-tissue adhesive was obtained from pooled donor plasma and was virally inactivated by a solvent- detergent treatment. Seven weeks after surgery all animals were killed and the vasal specimens were evaluated for gross patency and the incidence of sperm granuloma. Results: The control group had a patency rate of 85% and half had sperm granuloma. The experimental group had a patency rate of 92% and 40% had sperm granuloma; neither difference was significant. The mean operative time was significantly shorter for the fibrin glue-assisted vasovasostomy (P
KW - Fibrin adhesive
KW - Microsurgery
KW - Vasectomy reversal
UR - http://www.scopus.com/inward/record.url?scp=0030429258&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030429258&partnerID=8YFLogxK
M3 - Article
C2 - 8813927
AN - SCOPUS:0030429258
VL - 78
SP - 271
EP - 274
JO - BJU International
JF - BJU International
SN - 1464-4096
IS - 2
ER -