Delayed animal aging through the recovery of stem cell senescence by platelet rich plasma

Hen Yu Liu, Chiung Fang Huang, Tzu Chieh Lin, Ching Yu Tsai, Szu Yu Tina Chen, Alice Liu, Wei Hong Chen, Hong Jian Wei, Ming Fu Wang, David F. Williams, Win Ping Deng

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Aging is related to loss of functional stem cell accompanying loss of tissue and organ regeneration potentials. Previously, we demonstrated that the life span of ovariectomy-senescence accelerated mice (OVX-SAMP8) was significantly prolonged and similar to that of the congenic senescence-resistant strain of mice after platelet rich plasma (PRP)/embryonic fibroblast transplantation. The aim of this study is to investigate the potential of PRP for recovering cellular potential from senescence and then delaying animal aging. We first examined whether stem cells would be senescent in aged mice compared to young mice. Primary adipose derived stem cells (ADSCs) and bone marrow derived stem cells (BMSCs) were harvested from young and aged mice, and found that cell senescence was strongly correlated to animal aging. Subsequently, we demonstrated that PRP could recover cell potential from senescence, such as promote cell growth (cell proliferation and colony formation), increase osteogenesis, decrease adipogenesis, restore cell senescence related markers and resist the oxidative stress in stem cells from aged mice. The results also showed that PRP treatment in aged mice could delay mice aging as indicated by survival, body weight and aging phenotypes (behavior and gross morphology) in term of recovering the cellular potential of their stem cells compared to the results on aged control mice. In conclusion these findings showed that PRP has potential to delay aging through the recovery of stem cell senescence and could be used as an alternative medicine for tissue regeneration and future rejuvenation.

Original languageEnglish
Pages (from-to)9767-9776
Number of pages10
JournalBiomaterials
Volume35
Issue number37
DOIs
Publication statusPublished - Dec 1 2014

Fingerprint

Platelet-Rich Plasma
Cell Aging
Platelets
Stem cells
Animals
Stem Cells
Aging of materials
Plasmas
Recovery
Regeneration
Tissue regeneration
Oxidative stress
Cell proliferation
Cell growth
Fibroblasts
Rejuvenation
Adipogenesis
Medicine
Ovariectomy
Bone

Keywords

  • Adipose derived stem cells (ADSCs)
  • Bone marrow derived stem cells (BMSCs)
  • Delayed aging
  • Platelet rich plasma (PRP)
  • Senescence

ASJC Scopus subject areas

  • Biomaterials
  • Bioengineering
  • Ceramics and Composites
  • Mechanics of Materials
  • Biophysics
  • Medicine(all)

Cite this

Delayed animal aging through the recovery of stem cell senescence by platelet rich plasma. / Liu, Hen Yu; Huang, Chiung Fang; Lin, Tzu Chieh; Tsai, Ching Yu; Tina Chen, Szu Yu; Liu, Alice; Chen, Wei Hong; Wei, Hong Jian; Wang, Ming Fu; Williams, David F.; Deng, Win Ping.

In: Biomaterials, Vol. 35, No. 37, 01.12.2014, p. 9767-9776.

Research output: Contribution to journalArticle

Liu, HY, Huang, CF, Lin, TC, Tsai, CY, Tina Chen, SY, Liu, A, Chen, WH, Wei, HJ, Wang, MF, Williams, DF & Deng, WP 2014, 'Delayed animal aging through the recovery of stem cell senescence by platelet rich plasma', Biomaterials, vol. 35, no. 37, pp. 9767-9776. https://doi.org/10.1016/j.biomaterials.2014.08.034
Liu, Hen Yu ; Huang, Chiung Fang ; Lin, Tzu Chieh ; Tsai, Ching Yu ; Tina Chen, Szu Yu ; Liu, Alice ; Chen, Wei Hong ; Wei, Hong Jian ; Wang, Ming Fu ; Williams, David F. ; Deng, Win Ping. / Delayed animal aging through the recovery of stem cell senescence by platelet rich plasma. In: Biomaterials. 2014 ; Vol. 35, No. 37. pp. 9767-9776.
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