Degree of lipid saturation affects depressive-like behaviour and gut microbiota in mice

Hsiu-Chuan Lee, Yun-Chun Lo, Shao-Chuan Yu, Te-Hsuan Tung, I-Hsuan Lin, Shih-Yi Huang

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This study explored the effects of the degree of lipid saturation on depressive behaviour and gut microbiota in mice. Thirty-two mice were divided into normal (N), Prozac (NP), lard (L) and fish oil (F) groups. After a 12-week dietary intervention, the open field test (OFT) and the forced swim test (FST) were conducted before sacrifice. The mice in the L group exhibited anxiety-like behaviours in the OFT and depressive-like behaviours in the FST. A significant difference was observed in β-diversity indices between the L group and the F group. The abundance of Allobaculum and Bifidobacterium was significantly higher in the F group than in the L and N groups. The prefrontal cortex fatty acid composition was altered in various lipid-treated groups and was highly correlated with depressive-like behaviours. In conclusion, the degree of lipid saturation affects depressive-like behaviour, gut microbiota composition, and the prefrontal cortex fatty acid profile in mice.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalInternational Journal of Food Sciences and Nutrition
Publication statusE-pub ahead of print - Oct 23 2019


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