Degradable coronas comprising polyelectrolyte complexes of PDMAEMA and gelatin for pH-triggered antibiotic release

Hsiu Wen Yang, Jem Kun Chen, Shiao Wei Kuo, Ai Wei Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Carboxyl-modified polystyrene (PS) nanospheres were used as sacrificial cores upon which cross-linked gelatin (CGA) was assembled through successive immobilization with poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA), forming polyelectrolyte complexes (PECs) stabilized through electrostatic interactions and hydrogen bonding. The PEC coronas, possessing hollow structure, of the PEC CGA@PDMAEMA after removing the PS cores were obtained. At pH 2.2, the protonated PDMAEMA swelled the PEC coronas completely, leading to the disappearance of the inner cavities, which reappeared after increasing the pH to 5.5. Further increasing the pH to 8.1 caused the deprotonated PDMAEMA to collapse completely to cover the CGA surface, generating a solid shell. This pH-responsive structural change of the PEC coronas suggested that they could be used as drug capsules. Accordingly, amoxicillin (AMX) was loaded into the coronas as a medium to inhibit the bacterial viability of Escherichia coli and Staphylococcus aureus. Both of bacterial growth rates of E. coli and S. aureus in solution at pH 8.1 in the presence of the AMX-loaded PEC coronas did not change significantly within 8 h comparing with that in a blank experiment, indicating that the PEC coronas confined the AMX units within the hollow structure. With decrease of the pH to 5.5, the bacterial growth rates were inhibited obviously within 2 h relative to that in a blank experiment, confirming that the AMX units could be released from the PEC coronas by tuning pH value.

Original languageEnglish
Pages (from-to)2678-2687
Number of pages10
JournalPolymer
Volume55
Issue number11
DOIs
Publication statusPublished - May 27 2014

Fingerprint

Antibiotics
Gelatin
Polyelectrolytes
Anti-Bacterial Agents
Amoxicillin
Polystyrenes
Escherichia coli
poly(2-(dimethylamino)ethyl methacrylate)
Nanospheres
Coulomb interactions
Capsules
Hydrogen bonds
Tuning
Experiments
Pharmaceutical Preparations

Keywords

  • Corona
  • pH-triggered
  • Polyelectrolyte complex

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics

Cite this

Degradable coronas comprising polyelectrolyte complexes of PDMAEMA and gelatin for pH-triggered antibiotic release. / Yang, Hsiu Wen; Chen, Jem Kun; Kuo, Shiao Wei; Lee, Ai Wei.

In: Polymer, Vol. 55, No. 11, 27.05.2014, p. 2678-2687.

Research output: Contribution to journalArticle

Yang, Hsiu Wen ; Chen, Jem Kun ; Kuo, Shiao Wei ; Lee, Ai Wei. / Degradable coronas comprising polyelectrolyte complexes of PDMAEMA and gelatin for pH-triggered antibiotic release. In: Polymer. 2014 ; Vol. 55, No. 11. pp. 2678-2687.
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