Deep vein thrombosis associated with marked hyperhomocysteinemia and active pulmonary tuberculosis

Ng Zuan Chiu, Kou Gi Shyu

Research output: Contribution to journalArticle

Abstract

We report a 32-year-old male patient presented with acute deep vein thrombosis of his right leg after recent onset of active pulmonary tuberculosis. Marked hyperhomocysteinemia (> 50 μmol/L), folic acid deficiency, and abnormal coagulation profiles (elevations of fibrinogen and fibrinogen degradation product) were noted after a series of work-ups. After treatment with low-molecular-weight heparin, deep vein thrombosis improved. Serum homocysteine level returned to normal after folic acid and vitamin B12 supplementation for 2 months. After therapy with four-combined anti-tuberculosis drugs for 9 months, the pulmonary tuberculosis subsided. In the present case report, the cause of hyperhomocysteinemia may be related to folic acid deficiency and chronic renal insufficiency.

Original languageEnglish
Pages (from-to)186-191
Number of pages6
JournalActa Cardiologica Sinica
Volume23
Issue number3
Publication statusPublished - Sep 2007

Keywords

  • Deep vein thrombosis
  • Folic acid deficiency
  • Hypercoagulable state
  • Hyperhomocysteinemia
  • Pulmonary tuberculosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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