Deep sea water modulates blood pressure and exhibits hypolipidemic effects via the AMPK-ACC pathway

An in Vivo study

Ming Jyh Sheu, Pei Yu Chou, Wen Hsin Lin, Chun Hsu Pan, Yi Chung Chien, Yun Lung Chung, Fon Chang Liu, Chieh Hsi Wu

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Deep sea water (DSW), originally pumped from the Pacific Rim off the coast of Hualien County (Taiwan), and its mineral constituents, were concentrated by a low-temperature vacuum evaporation system to produce a hardness of approximately 400,000 mg/L of seawater mineral concentrate. The primary composition of this seawater mineral concentrate was ionic magnesium (Mg 2+), which was approximately 96,000 mg/L. Referring to the human recommended daily allowance (RDA) of magnesium, we diluted the mineral concentrate to three different dosages: 0.1 x DSW (equivalent to 3.75 mg Mg 2+/kg DSW); 1 x DSW (equivalent to 37.5 mg Mg2+/kg DSW); and 2 x DSW (equivalent to 75 mg Mg2+/kg DSW). Additionally, a magnesium chloride treatment was conducted for comparison with the DSW supplement. The study indicated that 0.1 x DSW, 1 x DSW and 2 x DSW decreased the systolic and diastolic pressures in spontaneous hypertensive rats in an eight-week experiment. DSW has been shown to reduce serum lipids and prevent atherogenesis in a hypercholesterolemic rabbit model. Our results demonstrated that 1 x DSW and 2 x DSW significantly suppressed the serum cholesterol levels, reduced the lipid accumulation in liver tissues, and limited aortic fatty streaks. These findings indicated that the antiatherogenic effects of DSW are associated with 5′-adenosine monophosphate-activated protein kinase (AMPK) stimulation and the consequent inhibition of phosphorylation of acetyl-CoA carboxylase (ACC) in atherosclerotic rabbits. We hypothesize that DSW could potentially be used as drinking water because it modulates blood pressure, reduces lipids, and prevents atherogenesis.

Original languageEnglish
Pages (from-to)2183-2202
Number of pages20
JournalMarine Drugs
Volume11
Issue number6
DOIs
Publication statusPublished - Jun 2013
Externally publishedYes

Fingerprint

Acetyl-CoA Carboxylase
Seawater
Adenosine Monophosphate
Protein Kinases
Blood Pressure
Minerals
Lipids
Magnesium
Atherosclerosis
Rabbits
Recommended Dietary Allowances
Magnesium Chloride

Keywords

  • Acetyl-CoA carboxylase
  • AMP-activated protein kinase
  • Atherosclerosis
  • Deep sea water
  • HMG-CoA reductase

ASJC Scopus subject areas

  • Drug Discovery

Cite this

Deep sea water modulates blood pressure and exhibits hypolipidemic effects via the AMPK-ACC pathway : An in Vivo study. / Sheu, Ming Jyh; Chou, Pei Yu; Lin, Wen Hsin; Pan, Chun Hsu; Chien, Yi Chung; Chung, Yun Lung; Liu, Fon Chang; Wu, Chieh Hsi.

In: Marine Drugs, Vol. 11, No. 6, 06.2013, p. 2183-2202.

Research output: Contribution to journalArticle

Sheu, Ming Jyh ; Chou, Pei Yu ; Lin, Wen Hsin ; Pan, Chun Hsu ; Chien, Yi Chung ; Chung, Yun Lung ; Liu, Fon Chang ; Wu, Chieh Hsi. / Deep sea water modulates blood pressure and exhibits hypolipidemic effects via the AMPK-ACC pathway : An in Vivo study. In: Marine Drugs. 2013 ; Vol. 11, No. 6. pp. 2183-2202.
@article{f60da7ab34314c22a23acb4eea38a9c9,
title = "Deep sea water modulates blood pressure and exhibits hypolipidemic effects via the AMPK-ACC pathway: An in Vivo study",
abstract = "Deep sea water (DSW), originally pumped from the Pacific Rim off the coast of Hualien County (Taiwan), and its mineral constituents, were concentrated by a low-temperature vacuum evaporation system to produce a hardness of approximately 400,000 mg/L of seawater mineral concentrate. The primary composition of this seawater mineral concentrate was ionic magnesium (Mg 2+), which was approximately 96,000 mg/L. Referring to the human recommended daily allowance (RDA) of magnesium, we diluted the mineral concentrate to three different dosages: 0.1 x DSW (equivalent to 3.75 mg Mg 2+/kg DSW); 1 x DSW (equivalent to 37.5 mg Mg2+/kg DSW); and 2 x DSW (equivalent to 75 mg Mg2+/kg DSW). Additionally, a magnesium chloride treatment was conducted for comparison with the DSW supplement. The study indicated that 0.1 x DSW, 1 x DSW and 2 x DSW decreased the systolic and diastolic pressures in spontaneous hypertensive rats in an eight-week experiment. DSW has been shown to reduce serum lipids and prevent atherogenesis in a hypercholesterolemic rabbit model. Our results demonstrated that 1 x DSW and 2 x DSW significantly suppressed the serum cholesterol levels, reduced the lipid accumulation in liver tissues, and limited aortic fatty streaks. These findings indicated that the antiatherogenic effects of DSW are associated with 5′-adenosine monophosphate-activated protein kinase (AMPK) stimulation and the consequent inhibition of phosphorylation of acetyl-CoA carboxylase (ACC) in atherosclerotic rabbits. We hypothesize that DSW could potentially be used as drinking water because it modulates blood pressure, reduces lipids, and prevents atherogenesis.",
keywords = "Acetyl-CoA carboxylase, AMP-activated protein kinase, Atherosclerosis, Deep sea water, HMG-CoA reductase",
author = "Sheu, {Ming Jyh} and Chou, {Pei Yu} and Lin, {Wen Hsin} and Pan, {Chun Hsu} and Chien, {Yi Chung} and Chung, {Yun Lung} and Liu, {Fon Chang} and Wu, {Chieh Hsi}",
year = "2013",
month = "6",
doi = "10.3390/md11062183",
language = "English",
volume = "11",
pages = "2183--2202",
journal = "Marine Drugs",
issn = "1660-3397",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "6",

}

TY - JOUR

T1 - Deep sea water modulates blood pressure and exhibits hypolipidemic effects via the AMPK-ACC pathway

T2 - An in Vivo study

AU - Sheu, Ming Jyh

AU - Chou, Pei Yu

AU - Lin, Wen Hsin

AU - Pan, Chun Hsu

AU - Chien, Yi Chung

AU - Chung, Yun Lung

AU - Liu, Fon Chang

AU - Wu, Chieh Hsi

PY - 2013/6

Y1 - 2013/6

N2 - Deep sea water (DSW), originally pumped from the Pacific Rim off the coast of Hualien County (Taiwan), and its mineral constituents, were concentrated by a low-temperature vacuum evaporation system to produce a hardness of approximately 400,000 mg/L of seawater mineral concentrate. The primary composition of this seawater mineral concentrate was ionic magnesium (Mg 2+), which was approximately 96,000 mg/L. Referring to the human recommended daily allowance (RDA) of magnesium, we diluted the mineral concentrate to three different dosages: 0.1 x DSW (equivalent to 3.75 mg Mg 2+/kg DSW); 1 x DSW (equivalent to 37.5 mg Mg2+/kg DSW); and 2 x DSW (equivalent to 75 mg Mg2+/kg DSW). Additionally, a magnesium chloride treatment was conducted for comparison with the DSW supplement. The study indicated that 0.1 x DSW, 1 x DSW and 2 x DSW decreased the systolic and diastolic pressures in spontaneous hypertensive rats in an eight-week experiment. DSW has been shown to reduce serum lipids and prevent atherogenesis in a hypercholesterolemic rabbit model. Our results demonstrated that 1 x DSW and 2 x DSW significantly suppressed the serum cholesterol levels, reduced the lipid accumulation in liver tissues, and limited aortic fatty streaks. These findings indicated that the antiatherogenic effects of DSW are associated with 5′-adenosine monophosphate-activated protein kinase (AMPK) stimulation and the consequent inhibition of phosphorylation of acetyl-CoA carboxylase (ACC) in atherosclerotic rabbits. We hypothesize that DSW could potentially be used as drinking water because it modulates blood pressure, reduces lipids, and prevents atherogenesis.

AB - Deep sea water (DSW), originally pumped from the Pacific Rim off the coast of Hualien County (Taiwan), and its mineral constituents, were concentrated by a low-temperature vacuum evaporation system to produce a hardness of approximately 400,000 mg/L of seawater mineral concentrate. The primary composition of this seawater mineral concentrate was ionic magnesium (Mg 2+), which was approximately 96,000 mg/L. Referring to the human recommended daily allowance (RDA) of magnesium, we diluted the mineral concentrate to three different dosages: 0.1 x DSW (equivalent to 3.75 mg Mg 2+/kg DSW); 1 x DSW (equivalent to 37.5 mg Mg2+/kg DSW); and 2 x DSW (equivalent to 75 mg Mg2+/kg DSW). Additionally, a magnesium chloride treatment was conducted for comparison with the DSW supplement. The study indicated that 0.1 x DSW, 1 x DSW and 2 x DSW decreased the systolic and diastolic pressures in spontaneous hypertensive rats in an eight-week experiment. DSW has been shown to reduce serum lipids and prevent atherogenesis in a hypercholesterolemic rabbit model. Our results demonstrated that 1 x DSW and 2 x DSW significantly suppressed the serum cholesterol levels, reduced the lipid accumulation in liver tissues, and limited aortic fatty streaks. These findings indicated that the antiatherogenic effects of DSW are associated with 5′-adenosine monophosphate-activated protein kinase (AMPK) stimulation and the consequent inhibition of phosphorylation of acetyl-CoA carboxylase (ACC) in atherosclerotic rabbits. We hypothesize that DSW could potentially be used as drinking water because it modulates blood pressure, reduces lipids, and prevents atherogenesis.

KW - Acetyl-CoA carboxylase

KW - AMP-activated protein kinase

KW - Atherosclerosis

KW - Deep sea water

KW - HMG-CoA reductase

UR - http://www.scopus.com/inward/record.url?scp=84879493711&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879493711&partnerID=8YFLogxK

U2 - 10.3390/md11062183

DO - 10.3390/md11062183

M3 - Article

VL - 11

SP - 2183

EP - 2202

JO - Marine Drugs

JF - Marine Drugs

SN - 1660-3397

IS - 6

ER -