Decreasing levels of anti-Nef antibody correlate with increasing HIV type 1 viral loads and AIDS disease progression

Yi Ming A. Chen, Rung Huei Lin, Cheng Ming Lee, Chong Yau Fu, Shou Chien Chen, Wan Jr Syu

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

To study the association between anti-Gag and anti-Nef antibody reactivities and their correlations with disease progression, 174 HIV-1/AIDS patients were followed up for 1 year after they received triple therapy. The antibody reactivities were analyzed using a Western blot test with recombinant Gag and Nef proteins. The results showed that decreasing levels of anti-Gag or anti-Nef antibody correlate with disease progression defined by HIV-1 viral loads or T4 cell counts. After receiving triple treatment for 1 year, 8 of 38 (21.1%) Nef antibody-negative patients became positive, while only 9 of 125 (7.2%) Nef antibody-positive persons lost the antibody reactivity (p < 0.01). Therefore, HIV-1 Nef may serve as a clinical marker of disease progression.

Original languageEnglish
Pages (from-to)43-50
Number of pages8
JournalAIDS Research and Human Retroviruses
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 1 1999
Externally publishedYes

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Viral Load
Disease Progression
HIV-1
Anti-Idiotypic Antibodies
Acquired Immunodeficiency Syndrome
Antibodies
nef Gene Products
CD4-Positive T-Lymphocytes
gag Gene Products
Recombinant Proteins
Cell Count
Biomarkers
Western Blotting
Therapeutics

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Decreasing levels of anti-Nef antibody correlate with increasing HIV type 1 viral loads and AIDS disease progression. / Chen, Yi Ming A.; Lin, Rung Huei; Lee, Cheng Ming; Fu, Chong Yau; Chen, Shou Chien; Syu, Wan Jr.

In: AIDS Research and Human Retroviruses, Vol. 15, No. 1, 01.01.1999, p. 43-50.

Research output: Contribution to journalArticle

Chen, Yi Ming A. ; Lin, Rung Huei ; Lee, Cheng Ming ; Fu, Chong Yau ; Chen, Shou Chien ; Syu, Wan Jr. / Decreasing levels of anti-Nef antibody correlate with increasing HIV type 1 viral loads and AIDS disease progression. In: AIDS Research and Human Retroviruses. 1999 ; Vol. 15, No. 1. pp. 43-50.
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