Decreased risk of stroke in patients with traumatic brain injury receiving acupuncture treatment: A population-based retrospective cohort study

Chun Chuan Shih, Yi Ting Hsu, Hwang Huei Wang, Ta Liang Chen, Chin Chuan Tsai, Hsin Long Lane, Chun Chieh Yeh, Fung Chang Sung, Wen Ta Chiu, Yih Giun Cherng, Chien Chang Liao

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Patients with traumatic brain injury (TBI) face increased risk of stroke. Whether acupuncture can help to protect TBI patients from stroke has not previously been studied. Methods: Taiwan's National Health Insurance Research Database was used to conduct a retrospective cohort study of 7409 TBI patients receiving acupuncture treatment and 29,636 propensity-score-matched TBI patients without acupuncture treatment in 2000-2008 as controls. Both TBI cohorts were followed until the end of 2010 and adjusted for immortal time to measure the incidence and adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) of new-onset stroke in the multivariable Cox proportional hazard models. Results: TBI patients with acupuncture treatment (4.9 per 1000 person-years) had a lower incidence of stroke compared with those without acupuncture treatment (7.5 per 1000 person-years), with a HR of 0.59 (95% CI = 0.50-0.69) after adjustment for sociodemographics, coexisting medical conditions and medications. The association between acupuncture treatment and stroke risk was investigated by sex and age group (20-44, 45-64, and ≥65 years). The probability curve with log-rank test showed that TBI patients receiving acupuncture treatment had a lower probability of stroke than those without acupuncture treatment during the follow-up period (p

Original languageEnglish
Article numbere89208
JournalPLoS One
Volume9
Issue number2
DOIs
Publication statusPublished - Feb 19 2014

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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