Abstract
Background/Purpose: Circulating retinol binding protein 4 (RBP4) is associated with a variety of obesity-related diseases. This study investigated whether there were aberrant concentrations of RBP4 in cholesterol gallstone disease. Methods: Serum RBP4 levels of 100 cholesterol gallstone patients and 147 healthy controls were measured by enzyme-linked immunosorbent assay and further correlated with clinical and biochemical characteristics, including insulin resistance and renal function. Gallstone specimens were obtained during laparoscopic cholecystectomy and analyzed for their chemical composition using Fourier transform infrared spectroscopy. Results: Significantly lower serum RBP4 levels were found in patients with cholesterol gallstones in comparison with controls (30.57 ± 13.64 mg/L vs. 41.52 ± 20.25 mg/L, p
| Original language | English |
|---|---|
| Pages (from-to) | 422-429 |
| Number of pages | 8 |
| Journal | Journal of the Formosan Medical Association = Taiwan yi zhi |
| Volume | 109 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2010 |
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Keywords
- adipokine
- cholesterol gallstone
- insulin resistance
- renal function
- retinol binding protein 4
ASJC Scopus subject areas
- Medicine(all)
Cite this
Decreased Retinol Binding Protein 4 Concentrations are Associated With Cholesterol Gallstone Disease. / Wang, Shen Nien; Yeh, Yao Tsung; Wang, Sen Teh; Chen, Yi Ling; Chuang, Shih Chang; Ker, Chen Guo; Lee, King Teh.
In: Journal of the Formosan Medical Association = Taiwan yi zhi, Vol. 109, No. 6, 06.2010, p. 422-429.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Decreased Retinol Binding Protein 4 Concentrations are Associated With Cholesterol Gallstone Disease
AU - Wang, Shen Nien
AU - Yeh, Yao Tsung
AU - Wang, Sen Teh
AU - Chen, Yi Ling
AU - Chuang, Shih Chang
AU - Ker, Chen Guo
AU - Lee, King Teh
PY - 2010/6
Y1 - 2010/6
N2 - Background/Purpose: Circulating retinol binding protein 4 (RBP4) is associated with a variety of obesity-related diseases. This study investigated whether there were aberrant concentrations of RBP4 in cholesterol gallstone disease. Methods: Serum RBP4 levels of 100 cholesterol gallstone patients and 147 healthy controls were measured by enzyme-linked immunosorbent assay and further correlated with clinical and biochemical characteristics, including insulin resistance and renal function. Gallstone specimens were obtained during laparoscopic cholecystectomy and analyzed for their chemical composition using Fourier transform infrared spectroscopy. Results: Significantly lower serum RBP4 levels were found in patients with cholesterol gallstones in comparison with controls (30.57 ± 13.64 mg/L vs. 41.52 ± 20.25 mg/L, p
AB - Background/Purpose: Circulating retinol binding protein 4 (RBP4) is associated with a variety of obesity-related diseases. This study investigated whether there were aberrant concentrations of RBP4 in cholesterol gallstone disease. Methods: Serum RBP4 levels of 100 cholesterol gallstone patients and 147 healthy controls were measured by enzyme-linked immunosorbent assay and further correlated with clinical and biochemical characteristics, including insulin resistance and renal function. Gallstone specimens were obtained during laparoscopic cholecystectomy and analyzed for their chemical composition using Fourier transform infrared spectroscopy. Results: Significantly lower serum RBP4 levels were found in patients with cholesterol gallstones in comparison with controls (30.57 ± 13.64 mg/L vs. 41.52 ± 20.25 mg/L, p
KW - adipokine
KW - cholesterol gallstone
KW - insulin resistance
KW - renal function
KW - retinol binding protein 4
UR - http://www.scopus.com/inward/record.url?scp=77953671231&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953671231&partnerID=8YFLogxK
U2 - 10.1016/S0929-6646(10)60073-3
DO - 10.1016/S0929-6646(10)60073-3
M3 - Article
C2 - 20610143
AN - SCOPUS:77953671231
VL - 109
SP - 422
EP - 429
JO - Journal of the Formosan Medical Association
JF - Journal of the Formosan Medical Association
SN - 0929-6646
IS - 6
ER -