Decreased Retinol Binding Protein 4 Concentrations are Associated With Cholesterol Gallstone Disease

Shen Nien Wang, Yao Tsung Yeh, Sen Teh Wang, Yi Ling Chen, Shih Chang Chuang, Chen Guo Ker, King Teh Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)


Background/Purpose: Circulating retinol binding protein 4 (RBP4) is associated with a variety of obesity-related diseases. This study investigated whether there were aberrant concentrations of RBP4 in cholesterol gallstone disease. Methods: Serum RBP4 levels of 100 cholesterol gallstone patients and 147 healthy controls were measured by enzyme-linked immunosorbent assay and further correlated with clinical and biochemical characteristics, including insulin resistance and renal function. Gallstone specimens were obtained during laparoscopic cholecystectomy and analyzed for their chemical composition using Fourier transform infrared spectroscopy. Results: Significantly lower serum RBP4 levels were found in patients with cholesterol gallstones in comparison with controls (30.57 ± 13.64 mg/L vs. 41.52 ± 20.25 mg/L, p

Original languageEnglish
Pages (from-to)422-429
Number of pages8
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Issue number6
Publication statusPublished - Jun 2010



  • adipokine
  • cholesterol gallstone
  • insulin resistance
  • renal function
  • retinol binding protein 4

ASJC Scopus subject areas

  • Medicine(all)

Cite this