Decreased power but preserved bursting features of subthalamic neuronal signals in advanced Parkinson's patients under controlled desflurane inhalation anesthesia

Sheng Huang Lin, Hsin Yi Lai, Yu Chun Lo, Chin Chou, Yi Ting Chou, Shih Hung Yang, I. Sun, Bo Wei Chen, Ching Fu Wang, Guan Tze Liu, Fu Shan Jaw, Shin Yuan Chen, You Yin Chen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Deep brain stimulation (DBS) surgery of the subthalamic nucleus (STN) under general anesthesia (GA) had been used in Parkinson's disease (PD) patients who are unable tolerate awake surgery. The effect of anesthetics on intraoperative microelectrode recording (MER) remains unclear. Understanding the effect of anesthetics on MER is important in performing STN DBS surgery with general anesthesia. In this study, we retrospectively performed qualitive and quantitative analysis of STN MER in PD patients received STN DBS with controlled desflurane anesthesia or LA and compared their clinical outcome. From January 2005 to March 2006, 19 consecutive PD patients received bilateral STN DBS surgery in Hualien Tzu-Chi hospital under either desflurane GA (n = 10) or LA (n = 9). We used spike analysis (frequency and modified burst index [MBI]) and the Hilbert transform to obtain signal power measurements for background and spikes, and compared the characterizations of intraoperative microelectrode signals between the two groups. Additionally, STN firing pattern characteristics were determined using a combined approach based on the autocorrelogram and power spectral analysis, which was employed to investigate differences in the oscillatory activities between the groups. Clinical outcomes were assessed using the Unified Parkinson's Disease Rating Scale (UPDRS) before and after surgery. The results revealed burst firing was observed in both groups. The firing frequencies were greater in the LA group and MBI was comparable in both groups. Both the background and spikes were of significantly greater power in the LA group. The power spectra of the autocorrelograms were significantly higher in the GA group between 4 and 8 Hz. Clinical outcomes based on the UPDRS were comparable in both groups before and after DBS surgery. Under controlled light desflurane GA, burst features of the neuronal firing patterns are preserved in the STN, but power is reduced. Enhanced low-frequency (4-8 Hz) oscillations in the MERs for the GA group could be a characteristic signature of desflurane's effect on neurons in the STN.

Original languageEnglish
Article number701
JournalFrontiers in Neuroscience
Volume11
Issue numberDEC
DOIs
Publication statusPublished - Dec 12 2017

Fingerprint

Inhalation Anesthesia
Subthalamic Nucleus
Deep Brain Stimulation
General Anesthesia
Parkinson Disease
Microelectrodes
Anesthetics
desflurane
Anesthesia
Neurons
Light

Keywords

  • Deep brain stimulation
  • Desflurane general anesthesia
  • Low frequency oscillation
  • Microelectrode recording
  • Parkinson's disease
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Decreased power but preserved bursting features of subthalamic neuronal signals in advanced Parkinson's patients under controlled desflurane inhalation anesthesia. / Lin, Sheng Huang; Lai, Hsin Yi; Lo, Yu Chun; Chou, Chin; Chou, Yi Ting; Yang, Shih Hung; Sun, I.; Chen, Bo Wei; Wang, Ching Fu; Liu, Guan Tze; Jaw, Fu Shan; Chen, Shin Yuan; Chen, You Yin.

In: Frontiers in Neuroscience, Vol. 11, No. DEC, 701, 12.12.2017.

Research output: Contribution to journalArticle

Lin, Sheng Huang ; Lai, Hsin Yi ; Lo, Yu Chun ; Chou, Chin ; Chou, Yi Ting ; Yang, Shih Hung ; Sun, I. ; Chen, Bo Wei ; Wang, Ching Fu ; Liu, Guan Tze ; Jaw, Fu Shan ; Chen, Shin Yuan ; Chen, You Yin. / Decreased power but preserved bursting features of subthalamic neuronal signals in advanced Parkinson's patients under controlled desflurane inhalation anesthesia. In: Frontiers in Neuroscience. 2017 ; Vol. 11, No. DEC.
@article{c750f9101ff54a1cb9ad884dcf433983,
title = "Decreased power but preserved bursting features of subthalamic neuronal signals in advanced Parkinson's patients under controlled desflurane inhalation anesthesia",
abstract = "Deep brain stimulation (DBS) surgery of the subthalamic nucleus (STN) under general anesthesia (GA) had been used in Parkinson's disease (PD) patients who are unable tolerate awake surgery. The effect of anesthetics on intraoperative microelectrode recording (MER) remains unclear. Understanding the effect of anesthetics on MER is important in performing STN DBS surgery with general anesthesia. In this study, we retrospectively performed qualitive and quantitative analysis of STN MER in PD patients received STN DBS with controlled desflurane anesthesia or LA and compared their clinical outcome. From January 2005 to March 2006, 19 consecutive PD patients received bilateral STN DBS surgery in Hualien Tzu-Chi hospital under either desflurane GA (n = 10) or LA (n = 9). We used spike analysis (frequency and modified burst index [MBI]) and the Hilbert transform to obtain signal power measurements for background and spikes, and compared the characterizations of intraoperative microelectrode signals between the two groups. Additionally, STN firing pattern characteristics were determined using a combined approach based on the autocorrelogram and power spectral analysis, which was employed to investigate differences in the oscillatory activities between the groups. Clinical outcomes were assessed using the Unified Parkinson's Disease Rating Scale (UPDRS) before and after surgery. The results revealed burst firing was observed in both groups. The firing frequencies were greater in the LA group and MBI was comparable in both groups. Both the background and spikes were of significantly greater power in the LA group. The power spectra of the autocorrelograms were significantly higher in the GA group between 4 and 8 Hz. Clinical outcomes based on the UPDRS were comparable in both groups before and after DBS surgery. Under controlled light desflurane GA, burst features of the neuronal firing patterns are preserved in the STN, but power is reduced. Enhanced low-frequency (4-8 Hz) oscillations in the MERs for the GA group could be a characteristic signature of desflurane's effect on neurons in the STN.",
keywords = "Deep brain stimulation, Desflurane general anesthesia, Low frequency oscillation, Microelectrode recording, Parkinson's disease, Subthalamic nucleus",
author = "Lin, {Sheng Huang} and Lai, {Hsin Yi} and Lo, {Yu Chun} and Chin Chou and Chou, {Yi Ting} and Yang, {Shih Hung} and I. Sun and Chen, {Bo Wei} and Wang, {Ching Fu} and Liu, {Guan Tze} and Jaw, {Fu Shan} and Chen, {Shin Yuan} and Chen, {You Yin}",
year = "2017",
month = "12",
day = "12",
doi = "10.3389/fnins.2017.00701",
language = "English",
volume = "11",
journal = "Frontiers in Neuroscience",
issn = "1662-4548",
publisher = "Frontiers Research Foundation",
number = "DEC",

}

TY - JOUR

T1 - Decreased power but preserved bursting features of subthalamic neuronal signals in advanced Parkinson's patients under controlled desflurane inhalation anesthesia

AU - Lin, Sheng Huang

AU - Lai, Hsin Yi

AU - Lo, Yu Chun

AU - Chou, Chin

AU - Chou, Yi Ting

AU - Yang, Shih Hung

AU - Sun, I.

AU - Chen, Bo Wei

AU - Wang, Ching Fu

AU - Liu, Guan Tze

AU - Jaw, Fu Shan

AU - Chen, Shin Yuan

AU - Chen, You Yin

PY - 2017/12/12

Y1 - 2017/12/12

N2 - Deep brain stimulation (DBS) surgery of the subthalamic nucleus (STN) under general anesthesia (GA) had been used in Parkinson's disease (PD) patients who are unable tolerate awake surgery. The effect of anesthetics on intraoperative microelectrode recording (MER) remains unclear. Understanding the effect of anesthetics on MER is important in performing STN DBS surgery with general anesthesia. In this study, we retrospectively performed qualitive and quantitative analysis of STN MER in PD patients received STN DBS with controlled desflurane anesthesia or LA and compared their clinical outcome. From January 2005 to March 2006, 19 consecutive PD patients received bilateral STN DBS surgery in Hualien Tzu-Chi hospital under either desflurane GA (n = 10) or LA (n = 9). We used spike analysis (frequency and modified burst index [MBI]) and the Hilbert transform to obtain signal power measurements for background and spikes, and compared the characterizations of intraoperative microelectrode signals between the two groups. Additionally, STN firing pattern characteristics were determined using a combined approach based on the autocorrelogram and power spectral analysis, which was employed to investigate differences in the oscillatory activities between the groups. Clinical outcomes were assessed using the Unified Parkinson's Disease Rating Scale (UPDRS) before and after surgery. The results revealed burst firing was observed in both groups. The firing frequencies were greater in the LA group and MBI was comparable in both groups. Both the background and spikes were of significantly greater power in the LA group. The power spectra of the autocorrelograms were significantly higher in the GA group between 4 and 8 Hz. Clinical outcomes based on the UPDRS were comparable in both groups before and after DBS surgery. Under controlled light desflurane GA, burst features of the neuronal firing patterns are preserved in the STN, but power is reduced. Enhanced low-frequency (4-8 Hz) oscillations in the MERs for the GA group could be a characteristic signature of desflurane's effect on neurons in the STN.

AB - Deep brain stimulation (DBS) surgery of the subthalamic nucleus (STN) under general anesthesia (GA) had been used in Parkinson's disease (PD) patients who are unable tolerate awake surgery. The effect of anesthetics on intraoperative microelectrode recording (MER) remains unclear. Understanding the effect of anesthetics on MER is important in performing STN DBS surgery with general anesthesia. In this study, we retrospectively performed qualitive and quantitative analysis of STN MER in PD patients received STN DBS with controlled desflurane anesthesia or LA and compared their clinical outcome. From January 2005 to March 2006, 19 consecutive PD patients received bilateral STN DBS surgery in Hualien Tzu-Chi hospital under either desflurane GA (n = 10) or LA (n = 9). We used spike analysis (frequency and modified burst index [MBI]) and the Hilbert transform to obtain signal power measurements for background and spikes, and compared the characterizations of intraoperative microelectrode signals between the two groups. Additionally, STN firing pattern characteristics were determined using a combined approach based on the autocorrelogram and power spectral analysis, which was employed to investigate differences in the oscillatory activities between the groups. Clinical outcomes were assessed using the Unified Parkinson's Disease Rating Scale (UPDRS) before and after surgery. The results revealed burst firing was observed in both groups. The firing frequencies were greater in the LA group and MBI was comparable in both groups. Both the background and spikes were of significantly greater power in the LA group. The power spectra of the autocorrelograms were significantly higher in the GA group between 4 and 8 Hz. Clinical outcomes based on the UPDRS were comparable in both groups before and after DBS surgery. Under controlled light desflurane GA, burst features of the neuronal firing patterns are preserved in the STN, but power is reduced. Enhanced low-frequency (4-8 Hz) oscillations in the MERs for the GA group could be a characteristic signature of desflurane's effect on neurons in the STN.

KW - Deep brain stimulation

KW - Desflurane general anesthesia

KW - Low frequency oscillation

KW - Microelectrode recording

KW - Parkinson's disease

KW - Subthalamic nucleus

UR - http://www.scopus.com/inward/record.url?scp=85038009176&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85038009176&partnerID=8YFLogxK

U2 - 10.3389/fnins.2017.00701

DO - 10.3389/fnins.2017.00701

M3 - Article

AN - SCOPUS:85038009176

VL - 11

JO - Frontiers in Neuroscience

JF - Frontiers in Neuroscience

SN - 1662-4548

IS - DEC

M1 - 701

ER -