Decreased neural activity in reward circuitry during personal reference in abstinent alcoholics-A fMRI study

Moritz De Greck, Alexander Supady, Rene Thiemann, Claus Tempelmann, Bernhard Bogerts, Lukas Forschner, Klaus V. Ploetz, Georg Northoff

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Two of the most striking features in alcoholism are the irresistible craving for alcohol and the proceeding neglect of other activities and pleasures that were formerly relevant. Craving has been investigated extensively and is commonly due to a dysfunctional reward system. The neural basis of the neglect of self-relevant interests, which can be described as altered personal reference, and its association to the reward system, however, remains unclear. Using fMRI, we investigated neural activity during a paradigm that tested for both reward and personal reference with regard to the same stimuli, i.e., alcoholic and nonalcoholic pictures, in healthy subjects and abstinent alcoholic patients. Alcoholic patients showed slightly reduced signal changes in the brain stem adjacent to ventral tegmental area (VTA) and in the ventromedial prefrontal cortex (VMPFC) during the reward task, while we found no alterations in the right and left ventral striatum (VS). The same regions (VS, VTA, and VMPFC), however, showed reduced signal changes during personal reference with lack of neural differentiation between high and low referenced stimuli in alcoholic patients. In summary, we demonstrate for the first time neurophysiological alterations in reward circuitry during personal reference in alcoholic patients. Our results underline the important role of the reward circuitry during personal reference in the pathophysiology of alcohol addiction. Hum Brain Mapp 30:1691-1704, 2009. VVC 2008 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)1691-1704
Number of pages14
JournalHuman Brain Mapping
Volume30
Issue number5
DOIs
Publication statusPublished - May 2009

Fingerprint

Alcoholics
Reward
Magnetic Resonance Imaging
Ventral Tegmental Area
Prefrontal Cortex
Alcoholism
Pleasure
Brain Stem
Healthy Volunteers
Alcohols
Brain

Keywords

  • Addiction
  • Alcoholism
  • Brain imaging
  • FMRI
  • Personal reference
  • Reward

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Decreased neural activity in reward circuitry during personal reference in abstinent alcoholics-A fMRI study. / De Greck, Moritz; Supady, Alexander; Thiemann, Rene; Tempelmann, Claus; Bogerts, Bernhard; Forschner, Lukas; Ploetz, Klaus V.; Northoff, Georg.

In: Human Brain Mapping, Vol. 30, No. 5, 05.2009, p. 1691-1704.

Research output: Contribution to journalArticle

De Greck, M, Supady, A, Thiemann, R, Tempelmann, C, Bogerts, B, Forschner, L, Ploetz, KV & Northoff, G 2009, 'Decreased neural activity in reward circuitry during personal reference in abstinent alcoholics-A fMRI study', Human Brain Mapping, vol. 30, no. 5, pp. 1691-1704. https://doi.org/10.1002/hbm.20634
De Greck M, Supady A, Thiemann R, Tempelmann C, Bogerts B, Forschner L et al. Decreased neural activity in reward circuitry during personal reference in abstinent alcoholics-A fMRI study. Human Brain Mapping. 2009 May;30(5):1691-1704. https://doi.org/10.1002/hbm.20634
De Greck, Moritz ; Supady, Alexander ; Thiemann, Rene ; Tempelmann, Claus ; Bogerts, Bernhard ; Forschner, Lukas ; Ploetz, Klaus V. ; Northoff, Georg. / Decreased neural activity in reward circuitry during personal reference in abstinent alcoholics-A fMRI study. In: Human Brain Mapping. 2009 ; Vol. 30, No. 5. pp. 1691-1704.
@article{97397efe19b649e2878031f8db1bffcd,
title = "Decreased neural activity in reward circuitry during personal reference in abstinent alcoholics-A fMRI study",
abstract = "Two of the most striking features in alcoholism are the irresistible craving for alcohol and the proceeding neglect of other activities and pleasures that were formerly relevant. Craving has been investigated extensively and is commonly due to a dysfunctional reward system. The neural basis of the neglect of self-relevant interests, which can be described as altered personal reference, and its association to the reward system, however, remains unclear. Using fMRI, we investigated neural activity during a paradigm that tested for both reward and personal reference with regard to the same stimuli, i.e., alcoholic and nonalcoholic pictures, in healthy subjects and abstinent alcoholic patients. Alcoholic patients showed slightly reduced signal changes in the brain stem adjacent to ventral tegmental area (VTA) and in the ventromedial prefrontal cortex (VMPFC) during the reward task, while we found no alterations in the right and left ventral striatum (VS). The same regions (VS, VTA, and VMPFC), however, showed reduced signal changes during personal reference with lack of neural differentiation between high and low referenced stimuli in alcoholic patients. In summary, we demonstrate for the first time neurophysiological alterations in reward circuitry during personal reference in alcoholic patients. Our results underline the important role of the reward circuitry during personal reference in the pathophysiology of alcohol addiction. Hum Brain Mapp 30:1691-1704, 2009. VVC 2008 Wiley-Liss, Inc.",
keywords = "Addiction, Alcoholism, Brain imaging, FMRI, Personal reference, Reward",
author = "{De Greck}, Moritz and Alexander Supady and Rene Thiemann and Claus Tempelmann and Bernhard Bogerts and Lukas Forschner and Ploetz, {Klaus V.} and Georg Northoff",
year = "2009",
month = "5",
doi = "10.1002/hbm.20634",
language = "English",
volume = "30",
pages = "1691--1704",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - Decreased neural activity in reward circuitry during personal reference in abstinent alcoholics-A fMRI study

AU - De Greck, Moritz

AU - Supady, Alexander

AU - Thiemann, Rene

AU - Tempelmann, Claus

AU - Bogerts, Bernhard

AU - Forschner, Lukas

AU - Ploetz, Klaus V.

AU - Northoff, Georg

PY - 2009/5

Y1 - 2009/5

N2 - Two of the most striking features in alcoholism are the irresistible craving for alcohol and the proceeding neglect of other activities and pleasures that were formerly relevant. Craving has been investigated extensively and is commonly due to a dysfunctional reward system. The neural basis of the neglect of self-relevant interests, which can be described as altered personal reference, and its association to the reward system, however, remains unclear. Using fMRI, we investigated neural activity during a paradigm that tested for both reward and personal reference with regard to the same stimuli, i.e., alcoholic and nonalcoholic pictures, in healthy subjects and abstinent alcoholic patients. Alcoholic patients showed slightly reduced signal changes in the brain stem adjacent to ventral tegmental area (VTA) and in the ventromedial prefrontal cortex (VMPFC) during the reward task, while we found no alterations in the right and left ventral striatum (VS). The same regions (VS, VTA, and VMPFC), however, showed reduced signal changes during personal reference with lack of neural differentiation between high and low referenced stimuli in alcoholic patients. In summary, we demonstrate for the first time neurophysiological alterations in reward circuitry during personal reference in alcoholic patients. Our results underline the important role of the reward circuitry during personal reference in the pathophysiology of alcohol addiction. Hum Brain Mapp 30:1691-1704, 2009. VVC 2008 Wiley-Liss, Inc.

AB - Two of the most striking features in alcoholism are the irresistible craving for alcohol and the proceeding neglect of other activities and pleasures that were formerly relevant. Craving has been investigated extensively and is commonly due to a dysfunctional reward system. The neural basis of the neglect of self-relevant interests, which can be described as altered personal reference, and its association to the reward system, however, remains unclear. Using fMRI, we investigated neural activity during a paradigm that tested for both reward and personal reference with regard to the same stimuli, i.e., alcoholic and nonalcoholic pictures, in healthy subjects and abstinent alcoholic patients. Alcoholic patients showed slightly reduced signal changes in the brain stem adjacent to ventral tegmental area (VTA) and in the ventromedial prefrontal cortex (VMPFC) during the reward task, while we found no alterations in the right and left ventral striatum (VS). The same regions (VS, VTA, and VMPFC), however, showed reduced signal changes during personal reference with lack of neural differentiation between high and low referenced stimuli in alcoholic patients. In summary, we demonstrate for the first time neurophysiological alterations in reward circuitry during personal reference in alcoholic patients. Our results underline the important role of the reward circuitry during personal reference in the pathophysiology of alcohol addiction. Hum Brain Mapp 30:1691-1704, 2009. VVC 2008 Wiley-Liss, Inc.

KW - Addiction

KW - Alcoholism

KW - Brain imaging

KW - FMRI

KW - Personal reference

KW - Reward

UR - http://www.scopus.com/inward/record.url?scp=63149180288&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=63149180288&partnerID=8YFLogxK

U2 - 10.1002/hbm.20634

DO - 10.1002/hbm.20634

M3 - Article

C2 - 18711709

AN - SCOPUS:63149180288

VL - 30

SP - 1691

EP - 1704

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

IS - 5

ER -