@article{9714bef1637948a69baa5a9347332b8f,
title = "Decreased incidence of hepatocellular carcinoma in hepatitis B vaccinees: A 20-year follow-up study",
abstract = "Background Hepatitis B virus (HBV) infection is a major cause of hepatocellular carcinoma. This population-based study aimed to investigate whether prevention of hepatocellular carcinoma by the universal Taiwanese HBV vaccine program, launched in July 1984, has extended beyond childhood and to identify the predictors of hepatocellular carcinoma for vaccinated birth cohorts.MethodsData on 1958 patients with hepatocellular carcinoma who were aged 6-29 years at diagnosis in Taiwan between 1983 and 2004 were collected from two national hepatocellular carcinoma registries. Age-and sex-specific incidence among vaccinated and unvaccinated birth cohorts were analyzed by using Poisson regression models. All statistical tests were two-sided. Records of 64 hepatocellular carcinoma patients and 5524435 HBV vaccinees who were born after the initiation of the vaccination program were compared for HBV immunization characteristics during infancy and prenatal maternal hepatitis B surface antigen (HBsAg) and e antigen (HBeAg) serostatus.ResultsHepatocellular carcinoma incidence was statistically significantly lower among children aged 6-19 years in vaccinated compared with unvaccinated birth cohorts (64 hepatocellular cancers among vaccinees in 37709304 person-years vs 444 cancers in unvaccinated subjects in 78496406 person-years, showing an age-and sex-adjusted relative risk of 0.31, P ",
keywords = "hepatitis B surface antigen, hepatitis B vaccine, hepatitis B(e) antigen, adult, article, child, controlled study, female, follow up, health program, hepatitis B, human, incidence, liver cell carcinoma, major clinical study, male, perinatal infection, preschool child, priority journal, risk factor, sex difference, Taiwan, Adolescent, Adult, Age Distribution, Carcinoma, Hepatocellular, Child, Female, Follow-Up Studies, Hepatitis B e Antigens, Hepatitis B Surface Antigens, Hepatitis B Vaccines, Humans, Incidence, Liver Neoplasms, Male, Mothers, Multivariate Analysis, Odds Ratio, Registries, Sex Distribution, Young Adult",
author = "Mei-Hwei Chang and San-Lin You and Chien-Jen Chen and Chun-Jen Liu and Chuan-Mo Lee and Shi-Ming Lin and Heng-Cheng Chu and Tzee-Chung Wu and Sheng-Shun Yang and Hsu-Sung Kuo and Ding-Shinn Chen",
note = "被引用次數：249 Export Date: 22 March 2016 CODEN: JNCIA 通訊地址: Chang, M.-H.; Department of Pediatrics, College of Public Health, National Taiwan University, Chung-Shan S. 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year = "2009",
doi = "10.1093/jnci/djp288",
language = "English",
volume = "101",
pages = "1348--1355",
journal = "Journal of the National Cancer Institute",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "19",
}