Decrease of bone morphogenetic protein-7 (BMP-7) and its type II receptor (BMP-RII) in kidney of type 1-like diabetic rats

J. T. Cheng, C. H. Yeh, C. K. Chang, M. F. Cheng, H. J. Lin

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Bone morphogenetic protein-7 (BMP-7) expression is known to be protective for renal damage during diabetic nephropathy and disappears early during the progression of diabetic nephropathy. However, changes in expression of BMP-7 and BMP-7 type II receptor (BMP-RII) during kidney nephropathy response to high glucose-induced oxidative stress remain unclear. In this study, we used streptozotocin-induced diabetic rats with diabetic nephropathy and treated them with insulin, phloridzin, or antioxidant tiron. The insulin, phloridzin, or tiron treatment improved the renal function and decreased fibronectin expression in the streptozotocin-induced diabetic rats. Both insulin and phloridzin could reverse the attenuation effects of hyperglycemia on BMP-7 and BMP-RII expressions in the kidneys of streptozotocin-induced diabetic rats through the correction of hyperglycemia. However, the decrease of BMP-7 and BMP-RII expressions in kidney of streptozotocin-induced diabetic rats could be reversed by tiron through decreasing the high glucose-induced oxidative stress but not through changing the levels of glucose. We further confirmed the effect on reversing the BMP-7 and BMP-RII expressions through decreasing oxidative stress by tiron treatment in high glucose exposed mesangial cells. Thus, we suggest that a decrease in oxidative stress is responsible for the improvement of renal function and recovery of renal BMP-7 and BMP-RII expression in streptozotocin-induced diabetic rats.

Original languageEnglish
Pages (from-to)605-611
Number of pages7
JournalHormone and Metabolic Research
Volume41
Issue number8
DOIs
Publication statusPublished - 2009

Fingerprint

Type II Bone Morphogenetic Protein Receptors
Bone Morphogenetic Protein 7
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt
Rats
Streptozocin
Oxidative stress
Kidney
Phlorhizin
Diabetic Nephropathies
Oxidative Stress
Glucose
Insulin
Hyperglycemia
Mesangial Cells
Recovery of Function
Fibronectins
Antioxidants
Recovery

Keywords

  • BMP-7
  • BMP-RII
  • Diabetic nephropathy
  • Oxidative stress

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Decrease of bone morphogenetic protein-7 (BMP-7) and its type II receptor (BMP-RII) in kidney of type 1-like diabetic rats. / Cheng, J. T.; Yeh, C. H.; Chang, C. K.; Cheng, M. F.; Lin, H. J.

In: Hormone and Metabolic Research, Vol. 41, No. 8, 2009, p. 605-611.

Research output: Contribution to journalArticle

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