@article{9acb937aa45b41b8a1f2305306f90845,
title = "Decrease in interleukin-21 in children suffering with severe atopic dermatitis",
abstract = "Background: Atopic dermatitis (AD) is a kind of eczema with an inflammatory, relapsing, non-contagious, and pruritic skin disorder. It is associated with the local infiltration of T helper type 2 (Th2) cells that secrete interleukin (IL)-4 and IL-5. IL-21 is a member of IL-2 family cytokine mainly expressed by activated CD4+ T lymphocytes. Until now, there is no clinical research in the expression of IL-21 in patients with AD. Methods: We analyzed serum levels of total immunoglobulin E (IgE), allergen-specific IgE, and cytokines IL-4, IL-5, IFN-γ, IL-17, and IL-21 in AD cases and controls. In addition, cytokine levels in the culture supernatants of peripheral blood mononuclear cells stimulated with anti-CD3 and anti-CD28 Abs, phytohemagglutin (PHA), or pokeweed mitogen (PWM) were measured. We also assessed clinical skin severity by Scoring of Atopic Dermatitis (SCORAD) index. Results: Our results showed that serum total IgE in the case group was significantly higher than that of control group (365.449±52.945 and 39.243±7.605IU/ml, respectively). Logistic regression analysis system reveals serum levels of IL-21 and IFN-γ are significantly correlated. However, IL-21 and IL-4, IL-21 and IL-5, as well as IL-21 and IL-17 showed no correlation. Conclusion: A significantly decreased level of IL-21 was observed in children suffering with severe AD compared with controls, suggesting that IL-21 may play a role in AD. {\textcopyright} 2011 John Wiley & Sons A/S.",
keywords = "Allergy, Atopic dermatitis, IgE isotype switch, Interleukin-21, CD28 antigen, CD3 antigen, CD4 antigen, gamma interferon, immunoglobulin E, interleukin 17, interleukin 21, interleukin 4, interleukin 5, phytohemagglutinin, pokeweed mitogen, article, atopic dermatitis, CD4+ T lymphocyte, child, clinical article, controlled study, cytokine release, disease severity, female, human, immunoglobulin blood level, male, peripheral blood mononuclear cell, priority journal, Scoring of Atopic Dermatitis index, scoring system, supernatant, T lymphocyte activation, Th2 cell, Antibodies, Monoclonal, Antigens, CD28, Antigens, CD3, Cells, Cultured, Child, Child, Preschool, Dermatitis, Atopic, Disease Progression, Down-Regulation, Female, Humans, Immunoglobulin E, Interferon-gamma, Interleukins, Male, Phytohemagglutinins, Pokeweed Mitogens, Th2 Cells",
author = "Sheng-Chieh Lin and Ya-Hui Chuang and Yao-Hsu Yang and Bor-Luen Chiang",
note = "被引用次數：8 Export Date: 7 April 2016 CODEN: PALUE 通訊地址: Chiang, B.-L.; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, No.7.Chung San South Road, Taipei, Taiwan; 電子郵件： gicmbor@ntu.edu.tw 化學物質/CAS: gamma interferon, 82115-62-6; immunoglobulin E, 37341-29-0; interleukin 21, 251100-02-4, 510787-82-3, 542817-56-1; phytohemagglutinin, 9008-97-3; pokeweed mitogen, 63231-57-2; Antibodies, Monoclonal; Antigens, CD28; Antigens, CD3; Immunoglobulin E, 37341-29-0; Interferon-gamma, 82115-62-6; Interleukins; Phytohemagglutinins; Pokeweed Mitogens; interleukin-21 參考文獻: Mosmann, T.R., Coffman, R.L., TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties (1998) Annu Rev Immunol, 7, pp. 145-173; Kabesch, M., Halonen, M., Holberg, C.J., A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children (2000) J Allergy Clin Immunol, 105, pp. 506-513; 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year = "2011",
doi = "10.1111/j.1399-3038.2011.01209.x",
language = "English",
volume = "22",
pages = "869--875",
journal = "Pediatric Allergy and Immunology",
issn = "0905-6157",
publisher = "Blackwell Munksgaard",
number = "8",
}
