Decrease in interferon gamma production and impairment of T-lymphocyte proliferation in peritoneal fluid of women with endometriosis

H. N. Ho, M. Y. Wu, K. H. Chao, C. D. Chen, S. U. Chen, H. F. Chen, S. Yang

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

OBJECTIVE: Our purpose was to verify regional immune modulations and to test the effect of gonadotropin-releasing hormone agonist in women with endometriosis. STUDY DESIGN: Concentrations of peritoneal cytokines, including interleukin-1β interleukin-2, soluble interleukin-2 receptor, interleukin-6, granulocyte-monocyte colony-stimulating factor, interferon gamma, and tumor necrosis factor-α were compared in women with and without endometriosis. Peritoneal cytokine and interleukin-2 production were examined by adding various mitogens to peritoneal fluid mononuclear cells of women with advanced endometriosis before and after gonadotropin-releasing hormone agonist treatment. RESULTS: A significant increase in peritoneal interleukin- 1β interleukin-6, and tumor necrosis factor-α and a decrease in interferon gamma were noted in women with endometriosis. After gonadotropin-releasing hormone agonist treatment interleukin-6 decreased and interferon gamma increased. A significant impairment of interleukin-2 production of peritoneal fluid mononuclear cells by phytohemagglutinin and pokeweed mitogen stimulation was demonstrated in endometriosis, and production could be restored after gonadotropin-releasing hormone agonist treatment. CONCLUSION: These results indicate that regional immunologic dysfunction might be invoked in the disease process of endometriosis.

Original languageEnglish
Pages (from-to)1236-1241
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume175
Issue number5
DOIs
Publication statusPublished - Jan 1 1996
Externally publishedYes

Fingerprint

Ascitic Fluid
Endometriosis
Interferon-gamma
Interleukin-6
T-Lymphocytes
Gonadotropin-Releasing Hormone
Interleukin-2
Interleukin-1beta
Tumor Necrosis Factor-alpha
Cytokines
Pokeweed Mitogens
Interleukin-2 Receptors
Phytohemagglutinins
Granulocyte Colony-Stimulating Factor
Mitogens
Monocytes
Therapeutics

Keywords

  • Endometriosis
  • gonadotropin-releasing hormone agonist
  • interferon gamma
  • interleukin-6
  • T-cell activation

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Decrease in interferon gamma production and impairment of T-lymphocyte proliferation in peritoneal fluid of women with endometriosis. / Ho, H. N.; Wu, M. Y.; Chao, K. H.; Chen, C. D.; Chen, S. U.; Chen, H. F.; Yang, S.

In: American Journal of Obstetrics and Gynecology, Vol. 175, No. 5, 01.01.1996, p. 1236-1241.

Research output: Contribution to journalArticle

Ho, H. N. ; Wu, M. Y. ; Chao, K. H. ; Chen, C. D. ; Chen, S. U. ; Chen, H. F. ; Yang, S. / Decrease in interferon gamma production and impairment of T-lymphocyte proliferation in peritoneal fluid of women with endometriosis. In: American Journal of Obstetrics and Gynecology. 1996 ; Vol. 175, No. 5. pp. 1236-1241.
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