Decision modelling of economic evaluation of intervention programme of breast cancer

Jung Chen Chang, Tony H H Chen, Stephen W. Duffy, Amy M F Yen, Sam L S Chen

Research output: Contribution to journalArticle

Abstract

Objectives Economic appraisal of an intervention is a complex and multivariable problem, with probabilistic issues related not only to clinical outcomes but also to costs and willingness to pay. Methods We provide a comprehensive framework for economic appraisal of a health intervention to prevent beast cancer mortality, involving probabilistic model of costs as well as of aspects of the disease process. The economic appraisal can give a range of probabilities of cost-effectiveness depending on willingness or ability to pay. Results We apply the method to the example of polychemotherapy for early breast cancer. Results indicate a 30% probability of cost-effectiveness for a willingness to pay of $60 000 per quality-adjusted life-year and around 50% for a threshold of $100 000. Conclusion The comprehensive economic appraisal model is a powerful tool for decision making over a range of economic environments.

Original languageEnglish
Pages (from-to)1282-1288
Number of pages7
JournalJournal of Evaluation in Clinical Practice
Volume16
Issue number6
DOIs
Publication statusPublished - Dec 2010
Externally publishedYes

Keywords

  • breast cancer
  • cost-benefit analysis
  • cost-effectiveness analysis
  • cost-utility analysis
  • decision model
  • Markov model
  • probabilistic approach

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health Policy

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