Abstract
Objectives Economic appraisal of an intervention is a complex and multivariable problem, with probabilistic issues related not only to clinical outcomes but also to costs and willingness to pay. Methods We provide a comprehensive framework for economic appraisal of a health intervention to prevent beast cancer mortality, involving probabilistic model of costs as well as of aspects of the disease process. The economic appraisal can give a range of probabilities of cost-effectiveness depending on willingness or ability to pay. Results We apply the method to the example of polychemotherapy for early breast cancer. Results indicate a 30% probability of cost-effectiveness for a willingness to pay of $60 000 per quality-adjusted life-year and around 50% for a threshold of $100 000. Conclusion The comprehensive economic appraisal model is a powerful tool for decision making over a range of economic environments.
| Original language | English |
|---|---|
| Pages (from-to) | 1282-1288 |
| Number of pages | 7 |
| Journal | Journal of Evaluation in Clinical Practice |
| Volume | 16 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2010 |
| Externally published | Yes |
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Keywords
- breast cancer
- cost-benefit analysis
- cost-effectiveness analysis
- cost-utility analysis
- decision model
- Markov model
- probabilistic approach
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Health Policy
Cite this
Decision modelling of economic evaluation of intervention programme of breast cancer. / Chang, Jung Chen; Chen, Tony H H; Duffy, Stephen W.; Yen, Amy M F; Chen, Sam L S.
In: Journal of Evaluation in Clinical Practice, Vol. 16, No. 6, 12.2010, p. 1282-1288.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Decision modelling of economic evaluation of intervention programme of breast cancer
AU - Chang, Jung Chen
AU - Chen, Tony H H
AU - Duffy, Stephen W.
AU - Yen, Amy M F
AU - Chen, Sam L S
PY - 2010/12
Y1 - 2010/12
N2 - Objectives Economic appraisal of an intervention is a complex and multivariable problem, with probabilistic issues related not only to clinical outcomes but also to costs and willingness to pay. Methods We provide a comprehensive framework for economic appraisal of a health intervention to prevent beast cancer mortality, involving probabilistic model of costs as well as of aspects of the disease process. The economic appraisal can give a range of probabilities of cost-effectiveness depending on willingness or ability to pay. Results We apply the method to the example of polychemotherapy for early breast cancer. Results indicate a 30% probability of cost-effectiveness for a willingness to pay of $60 000 per quality-adjusted life-year and around 50% for a threshold of $100 000. Conclusion The comprehensive economic appraisal model is a powerful tool for decision making over a range of economic environments.
AB - Objectives Economic appraisal of an intervention is a complex and multivariable problem, with probabilistic issues related not only to clinical outcomes but also to costs and willingness to pay. Methods We provide a comprehensive framework for economic appraisal of a health intervention to prevent beast cancer mortality, involving probabilistic model of costs as well as of aspects of the disease process. The economic appraisal can give a range of probabilities of cost-effectiveness depending on willingness or ability to pay. Results We apply the method to the example of polychemotherapy for early breast cancer. Results indicate a 30% probability of cost-effectiveness for a willingness to pay of $60 000 per quality-adjusted life-year and around 50% for a threshold of $100 000. Conclusion The comprehensive economic appraisal model is a powerful tool for decision making over a range of economic environments.
KW - breast cancer
KW - cost-benefit analysis
KW - cost-effectiveness analysis
KW - cost-utility analysis
KW - decision model
KW - Markov model
KW - probabilistic approach
UR - http://www.scopus.com/inward/record.url?scp=78650611329&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650611329&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2753.2009.01329.x
DO - 10.1111/j.1365-2753.2009.01329.x
M3 - Article
VL - 16
SP - 1282
EP - 1288
JO - Journal of Evaluation in Clinical Practice
JF - Journal of Evaluation in Clinical Practice
SN - 1356-1294
IS - 6
ER -