Abstract

The data in this article is related to the research article entitled, "Targeting of Multiple Oncogenic Signaling Pathways by Hsp90 Inhibitor Alone or in Combination with Berberine for Treatment of Colorectal Cancer" [1]. Overexpression of survivin induces resistance to various anticancer therapies such as chemotherapy and radiation therapy in colorectal cancer (CRC) cells. To determine significant correlations of biological functions/pathways with survivin, 4567 significant genes were analyzed from the GEO DataSet (GSE21815) of CRC and these were overlaid onto a global molecular network developed from information contained in the Ingenuity Pathway Analysis (IPA) database. The data here present the most significant disease and disordered biological functions, significant molecular/cellular functions and significant categories in physiological development/system functions which were associated with CRC. The top 10 canonical signaling pathways associated with CRC were categorize in order based on the level of statistical significance.

Original languageEnglish
Pages (from-to)235-238
Number of pages4
JournalData in Brief
Volume4
DOIs
Publication statusPublished - 2015

Fingerprint

cancer
statistical significance
system development
Disease

ASJC Scopus subject areas

  • General
  • Education

Cite this

@article{3765e4d20b01478fb17815ec6233a1c1,
title = "Data supporting the identification of compound for inhibition of survivin of colorectal cancer by using ingenuity pathway analysis of gene expression profiling of colorectal cancer tissues",
abstract = "The data in this article is related to the research article entitled, {"}Targeting of Multiple Oncogenic Signaling Pathways by Hsp90 Inhibitor Alone or in Combination with Berberine for Treatment of Colorectal Cancer{"} [1]. Overexpression of survivin induces resistance to various anticancer therapies such as chemotherapy and radiation therapy in colorectal cancer (CRC) cells. To determine significant correlations of biological functions/pathways with survivin, 4567 significant genes were analyzed from the GEO DataSet (GSE21815) of CRC and these were overlaid onto a global molecular network developed from information contained in the Ingenuity Pathway Analysis (IPA) database. The data here present the most significant disease and disordered biological functions, significant molecular/cellular functions and significant categories in physiological development/system functions which were associated with CRC. The top 10 canonical signaling pathways associated with CRC were categorize in order based on the level of statistical significance.",
author = "Lee, {Yi Chao} and Lee, {Jun Wei} and Huang, {Chi Chen} and Wu, {Ming Heng} and Lee, {Kuen Haur}",
year = "2015",
doi = "10.1016/j.dib.2015.05.017",
language = "English",
volume = "4",
pages = "235--238",
journal = "Data in Brief",
issn = "2352-3409",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Data supporting the identification of compound for inhibition of survivin of colorectal cancer by using ingenuity pathway analysis of gene expression profiling of colorectal cancer tissues

AU - Lee, Yi Chao

AU - Lee, Jun Wei

AU - Huang, Chi Chen

AU - Wu, Ming Heng

AU - Lee, Kuen Haur

PY - 2015

Y1 - 2015

N2 - The data in this article is related to the research article entitled, "Targeting of Multiple Oncogenic Signaling Pathways by Hsp90 Inhibitor Alone or in Combination with Berberine for Treatment of Colorectal Cancer" [1]. Overexpression of survivin induces resistance to various anticancer therapies such as chemotherapy and radiation therapy in colorectal cancer (CRC) cells. To determine significant correlations of biological functions/pathways with survivin, 4567 significant genes were analyzed from the GEO DataSet (GSE21815) of CRC and these were overlaid onto a global molecular network developed from information contained in the Ingenuity Pathway Analysis (IPA) database. The data here present the most significant disease and disordered biological functions, significant molecular/cellular functions and significant categories in physiological development/system functions which were associated with CRC. The top 10 canonical signaling pathways associated with CRC were categorize in order based on the level of statistical significance.

AB - The data in this article is related to the research article entitled, "Targeting of Multiple Oncogenic Signaling Pathways by Hsp90 Inhibitor Alone or in Combination with Berberine for Treatment of Colorectal Cancer" [1]. Overexpression of survivin induces resistance to various anticancer therapies such as chemotherapy and radiation therapy in colorectal cancer (CRC) cells. To determine significant correlations of biological functions/pathways with survivin, 4567 significant genes were analyzed from the GEO DataSet (GSE21815) of CRC and these were overlaid onto a global molecular network developed from information contained in the Ingenuity Pathway Analysis (IPA) database. The data here present the most significant disease and disordered biological functions, significant molecular/cellular functions and significant categories in physiological development/system functions which were associated with CRC. The top 10 canonical signaling pathways associated with CRC were categorize in order based on the level of statistical significance.

UR - http://www.scopus.com/inward/record.url?scp=84935002229&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84935002229&partnerID=8YFLogxK

U2 - 10.1016/j.dib.2015.05.017

DO - 10.1016/j.dib.2015.05.017

M3 - Article

AN - SCOPUS:84935002229

VL - 4

SP - 235

EP - 238

JO - Data in Brief

JF - Data in Brief

SN - 2352-3409

ER -