Damage from periorbital ageing to the multilayered structures and resilience of the skin in Chinese population

Chuh Kai Liao, Feng-Chou Tsai, Tsorng Harn Fong, Chien Ming Hu, Po Li Wei, Ching-Hua Su

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Ageing dynamically disrupts the multilayered supporting components of the skin that are held together by cell adhesion molecules (CAMs). Skin specimens from 33 female Chinese patients undergoing lower blepharoplasty were divided into three age groups and examined by haematoxylin and eosin (H&E) staining, immunohistochemistry (IHC) and Elastica-van Gieson (EVG) stains, western blotting, surface electron microscopy (SEM) and biomechanical tension analysis. The SEM density (skin surface topology) showed a negative linear relationship with age. The triangular pattern of the skin surface in the younger group gradually broke down into quadrangular and irregular patterns in the older group. Collagens and elastic fibres in the dermis showed anisotropy and decreased density in the older groups compared with the younger group, especially in the papillary dermis. Anisotropy means that physical properties differ according to the direction of measurement. E-cadherin and integrin αv (whose functions are to bind epidermal and dermal elements respectively) increased and decreased, respectively, in the oldest group. Skin resilience decreased significantly in this group under repetitive stress. In conclusion, a loss of skin surface textures, integrin αv expressions, epidermal-dermal connections and dermal compactness led to the multilayered structure of the skin becoming separated. This in turn decreased resilience during ageing. These findings may therefore explain why aged skins cannot tolerate repetitive facial expressions, and why this action produces further dynamic wrinkles.

Original languageEnglish
Pages (from-to)188-194
Number of pages7
JournalInternational Journal of Experimental Pathology
Volume94
Issue number3
DOIs
Publication statusPublished - Jun 2013

Keywords

  • Ageing
  • Cell adhesion molecules
  • Collagens
  • Elastic fibres
  • Skin resilience
  • Topology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology
  • Molecular Biology

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