D-Aspartic acid localization during postnatal development of rat adrenal gland

Kumiko Sakai, Hiroshi Homma, Jen Ai Lee, Takeshi Fukushima, Tomofumi Santa, Ken Tashiro, Takeshi Iwatsubo, Kazuhiro Imai

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Developmental changes in cellular localization of D-aspartic acid (D-Asp) were investigated in rat adrenal gland with polyclonal anti-D-Asp antibody. At 1 and 3 weeks of age, immunoreactivity (IR) toward this amino acid was intense in the cytoplasm of cells in the zona fasciculata (ZF) and zona reticularis (ZR) of the adrenal cortex but was less so in the zona glomerulosa (ZG). Conversely at 8 weeks of age, intense IR was observed in the ZG and less in the ZF and ZR. In the adrenal medulla, IR was evident in large clusters of cells which were identified as adrenaline-storing cells. The emergence of D-Asp in specific types of cells at distinct periods of development of rat adrenal gland suggests that this amino acid may have a physiological role in the maturation of the organ.

Original languageEnglish
Pages (from-to)433-436
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume235
Issue number2
DOIs
Publication statusPublished - Jun 18 1997
Externally publishedYes

Fingerprint

D-Aspartic Acid
Adrenal Glands
Rats
Zona Reticularis
Zona Fasciculata
Zona Glomerulosa
Amino Acids
Epinephrine
Cells
Adrenal Medulla
Antibodies
Adrenal Cortex
Cytoplasm
RHO(D) antibody

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

D-Aspartic acid localization during postnatal development of rat adrenal gland. / Sakai, Kumiko; Homma, Hiroshi; Lee, Jen Ai; Fukushima, Takeshi; Santa, Tomofumi; Tashiro, Ken; Iwatsubo, Takeshi; Imai, Kazuhiro.

In: Biochemical and Biophysical Research Communications, Vol. 235, No. 2, 18.06.1997, p. 433-436.

Research output: Contribution to journalArticle

Sakai, K, Homma, H, Lee, JA, Fukushima, T, Santa, T, Tashiro, K, Iwatsubo, T & Imai, K 1997, 'D-Aspartic acid localization during postnatal development of rat adrenal gland', Biochemical and Biophysical Research Communications, vol. 235, no. 2, pp. 433-436. https://doi.org/10.1006/bbrc.1997.6783
Sakai, Kumiko ; Homma, Hiroshi ; Lee, Jen Ai ; Fukushima, Takeshi ; Santa, Tomofumi ; Tashiro, Ken ; Iwatsubo, Takeshi ; Imai, Kazuhiro. / D-Aspartic acid localization during postnatal development of rat adrenal gland. In: Biochemical and Biophysical Research Communications. 1997 ; Vol. 235, No. 2. pp. 433-436.
@article{c5cb0e71524b4ad3b11882d262870b75,
title = "D-Aspartic acid localization during postnatal development of rat adrenal gland",
abstract = "Developmental changes in cellular localization of D-aspartic acid (D-Asp) were investigated in rat adrenal gland with polyclonal anti-D-Asp antibody. At 1 and 3 weeks of age, immunoreactivity (IR) toward this amino acid was intense in the cytoplasm of cells in the zona fasciculata (ZF) and zona reticularis (ZR) of the adrenal cortex but was less so in the zona glomerulosa (ZG). Conversely at 8 weeks of age, intense IR was observed in the ZG and less in the ZF and ZR. In the adrenal medulla, IR was evident in large clusters of cells which were identified as adrenaline-storing cells. The emergence of D-Asp in specific types of cells at distinct periods of development of rat adrenal gland suggests that this amino acid may have a physiological role in the maturation of the organ.",
author = "Kumiko Sakai and Hiroshi Homma and Lee, {Jen Ai} and Takeshi Fukushima and Tomofumi Santa and Ken Tashiro and Takeshi Iwatsubo and Kazuhiro Imai",
year = "1997",
month = "6",
day = "18",
doi = "10.1006/bbrc.1997.6783",
language = "English",
volume = "235",
pages = "433--436",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Elsevier B.V.",
number = "2",

}

TY - JOUR

T1 - D-Aspartic acid localization during postnatal development of rat adrenal gland

AU - Sakai, Kumiko

AU - Homma, Hiroshi

AU - Lee, Jen Ai

AU - Fukushima, Takeshi

AU - Santa, Tomofumi

AU - Tashiro, Ken

AU - Iwatsubo, Takeshi

AU - Imai, Kazuhiro

PY - 1997/6/18

Y1 - 1997/6/18

N2 - Developmental changes in cellular localization of D-aspartic acid (D-Asp) were investigated in rat adrenal gland with polyclonal anti-D-Asp antibody. At 1 and 3 weeks of age, immunoreactivity (IR) toward this amino acid was intense in the cytoplasm of cells in the zona fasciculata (ZF) and zona reticularis (ZR) of the adrenal cortex but was less so in the zona glomerulosa (ZG). Conversely at 8 weeks of age, intense IR was observed in the ZG and less in the ZF and ZR. In the adrenal medulla, IR was evident in large clusters of cells which were identified as adrenaline-storing cells. The emergence of D-Asp in specific types of cells at distinct periods of development of rat adrenal gland suggests that this amino acid may have a physiological role in the maturation of the organ.

AB - Developmental changes in cellular localization of D-aspartic acid (D-Asp) were investigated in rat adrenal gland with polyclonal anti-D-Asp antibody. At 1 and 3 weeks of age, immunoreactivity (IR) toward this amino acid was intense in the cytoplasm of cells in the zona fasciculata (ZF) and zona reticularis (ZR) of the adrenal cortex but was less so in the zona glomerulosa (ZG). Conversely at 8 weeks of age, intense IR was observed in the ZG and less in the ZF and ZR. In the adrenal medulla, IR was evident in large clusters of cells which were identified as adrenaline-storing cells. The emergence of D-Asp in specific types of cells at distinct periods of development of rat adrenal gland suggests that this amino acid may have a physiological role in the maturation of the organ.

UR - http://www.scopus.com/inward/record.url?scp=0031577183&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031577183&partnerID=8YFLogxK

U2 - 10.1006/bbrc.1997.6783

DO - 10.1006/bbrc.1997.6783

M3 - Article

C2 - 9199212

AN - SCOPUS:0031577183

VL - 235

SP - 433

EP - 436

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 2

ER -