D-Aspartate localization in the rat pituitary gland and retina

Jen Ai Lee, Hiroshi Homma, Ken Tashiro, Takeshi Iwatsubo, Kazuhiro Imai

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Rat pituitary gland and retina were probed with anti-D-aspartate (D-Asp) antibody previously prepared in this laboratory [Lee et al., Biochem. Biophys. Res. Commun., 231 (1997) 505-508]. D-Asp immunoreactivity (IR) was observed only in the posterior lobe of the pituitary gland of 3-day-old rats, whereas the anterior and posterior lobes were also positive in 3-week and 6- week-old rats, respectively. In the anterior lobe, intense IR was scattered throughout the lobe and the D-Asp-positive cells appeared to be prolactin- containing cells or some other very closely related type of cell. In the retina, D-Asp IR was observed only in the ganglion cell and nerve fiber region of 3-day-old rats. In contrast, during the transient increase in D-Asp levels in 7-day-old rats, D-Asp IR was additionally evident in regions where differentiating bipolar cells had begun to make contact with other types of cells. The functional relevance of D-Asp localization in these tissues is discussed.

Original languageEnglish
Pages (from-to)193-199
Number of pages7
JournalBrain Research
Volume838
Issue number1-2
DOIs
Publication statusPublished - Aug 14 1999
Externally publishedYes

Fingerprint

D-Aspartic Acid
Pituitary Gland
Retina
Posterior Pituitary Gland
Nerve Fibers
Ganglia
Prolactin
Antibodies

Keywords

  • D-Aspartate
  • Immunohistochemistry
  • Luteinizing hormone
  • Pituitary gland
  • Prolactin
  • Retina

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

D-Aspartate localization in the rat pituitary gland and retina. / Lee, Jen Ai; Homma, Hiroshi; Tashiro, Ken; Iwatsubo, Takeshi; Imai, Kazuhiro.

In: Brain Research, Vol. 838, No. 1-2, 14.08.1999, p. 193-199.

Research output: Contribution to journalArticle

Lee, JA, Homma, H, Tashiro, K, Iwatsubo, T & Imai, K 1999, 'D-Aspartate localization in the rat pituitary gland and retina', Brain Research, vol. 838, no. 1-2, pp. 193-199. https://doi.org/10.1016/S0006-8993(99)01718-7
Lee, Jen Ai ; Homma, Hiroshi ; Tashiro, Ken ; Iwatsubo, Takeshi ; Imai, Kazuhiro. / D-Aspartate localization in the rat pituitary gland and retina. In: Brain Research. 1999 ; Vol. 838, No. 1-2. pp. 193-199.
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