Cytotoxic steroidal saponins from Agave sisalana

Pi Yu Chen, Chin Hui Chen, Ching Chuan Kuo, Zong-Huei Li, Yueh Hsiung Kuo, Ching Kuo Lee

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Two new steroidal saponins, 8 and 10, along with 7 known steroidal sapogenins and saponins (1-7) and a furostanol saponin (9) were isolated from Agave sisalana Perrine ex Engelm. The structures of these two new compounds were identified and characterized by 1D and 2D NMR spectroscopy and mass spectrometry. In addition, acid hydrolysis and GC-FID were used to confirm the sugar moieties of 8 and 10. The cytotoxic effects of 1-10 on MCF-7, NCI-H460, and SF-268 cancer cells were evaluated, and among them, compound 10 proved to be the most cytotoxic with IC50 values of 1.2, 3.8, and 1.5 μM, respectively.

Original languageEnglish
Pages (from-to)929-933
Number of pages5
JournalPlanta Medica
Volume77
Issue number9
DOIs
Publication statusPublished - 2011

Fingerprint

Agave
Saponins
Sapogenins
Sugars
Nuclear magnetic resonance spectroscopy
Inhibitory Concentration 50
Mass spectrometry
Hydrolysis
Mass Spectrometry
Magnetic Resonance Spectroscopy
Cells
Acids
Neoplasms

Keywords

  • Agavaceae
  • Agave sisalana
  • MCF-7 cells
  • NCI-H460 cells
  • SF-268 cells
  • steroidal saponin

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Chen, P. Y., Chen, C. H., Kuo, C. C., Li, Z-H., Kuo, Y. H., & Lee, C. K. (2011). Cytotoxic steroidal saponins from Agave sisalana. Planta Medica, 77(9), 929-933. https://doi.org/10.1055/s-0030-1250672

Cytotoxic steroidal saponins from Agave sisalana. / Chen, Pi Yu; Chen, Chin Hui; Kuo, Ching Chuan; Li, Zong-Huei; Kuo, Yueh Hsiung; Lee, Ching Kuo.

In: Planta Medica, Vol. 77, No. 9, 2011, p. 929-933.

Research output: Contribution to journalArticle

Chen, PY, Chen, CH, Kuo, CC, Li, Z-H, Kuo, YH & Lee, CK 2011, 'Cytotoxic steroidal saponins from Agave sisalana', Planta Medica, vol. 77, no. 9, pp. 929-933. https://doi.org/10.1055/s-0030-1250672
Chen, Pi Yu ; Chen, Chin Hui ; Kuo, Ching Chuan ; Li, Zong-Huei ; Kuo, Yueh Hsiung ; Lee, Ching Kuo. / Cytotoxic steroidal saponins from Agave sisalana. In: Planta Medica. 2011 ; Vol. 77, No. 9. pp. 929-933.
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