Cytotoxic steroidal saponins from Agave sisalana

Pi Yu Chen, Chin Hui Chen, Ching Chuan Kuo, Zong-Huei Li, Yueh Hsiung Kuo, Ching Kuo Lee

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26 Citations (Scopus)

Abstract

Two new steroidal saponins, 8 and 10, along with 7 known steroidal sapogenins and saponins (1-7) and a furostanol saponin (9) were isolated from Agave sisalana Perrine ex Engelm. The structures of these two new compounds were identified and characterized by 1D and 2D NMR spectroscopy and mass spectrometry. In addition, acid hydrolysis and GC-FID were used to confirm the sugar moieties of 8 and 10. The cytotoxic effects of 1-10 on MCF-7, NCI-H460, and SF-268 cancer cells were evaluated, and among them, compound 10 proved to be the most cytotoxic with IC50 values of 1.2, 3.8, and 1.5 μM, respectively.

Original languageEnglish
Pages (from-to)929-933
Number of pages5
JournalPlanta Medica
Volume77
Issue number9
DOIs
Publication statusPublished - 2011

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Keywords

  • Agavaceae
  • Agave sisalana
  • MCF-7 cells
  • NCI-H460 cells
  • SF-268 cells
  • steroidal saponin

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Chen, P. Y., Chen, C. H., Kuo, C. C., Li, Z-H., Kuo, Y. H., & Lee, C. K. (2011). Cytotoxic steroidal saponins from Agave sisalana. Planta Medica, 77(9), 929-933. https://doi.org/10.1055/s-0030-1250672