Cytotoxic protobassic acid saponins from the kernels of Palaquium formosanum

Hsin Yi Chen, Ju Fang Liu, Sheng Fa Tsai, Yi Li Lin, Shoei Sheng Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Bioassay guided fractionation and separation of the EtOH extract of the kernels of Palaquium formosanum against PC-3 cells via Sephadex LH-20 and reverse phase C-18 columns led to the isolation of 13 protobassic saponins. One of these saponins is new and was characterized as 3‴-O-rhamnopyranosyl-arganin C, a bisdesmoside of 16α-hydroxyprotobassic acid at the C-3 and C-28 positions. The structures of these compounds were determined on the basis of 1D NMR ( 1 H, 13 C), 2D NMR ( 1 H– 1 H COSY, HSQC, HMBC, and NOESY), and selectively excited 1D TOCSY spectroscopic analyses and MS data, and comparison with literature data. Bioassay of these compounds and five additional compounds, isolated from Planchonella obovata leaf, against PC-3 prostate cancer cells indicated arganin C to be the most potent one with the IC 50 value of 13.8 μM. Some structure and activity relationships were also drawn.

Original languageEnglish
Pages (from-to)557-564
Number of pages8
JournalJournal of Food and Drug Analysis
Volume26
Issue number2
DOIs
Publication statusPublished - Apr 2018

Keywords

  • 1D TOCSY
  • Cytotoxicity
  • Palaquium formosanum Hayata
  • Protobassic acid saponins
  • Sapotaceae

ASJC Scopus subject areas

  • Food Science
  • Pharmacology

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