Cytotoxic constituents from Podocarpus fasciculus

Yu Jen Kuo, Shy Yuan Hwang, Ming Der Wu, Chia Ching Liao, Yu Han Liang, Yao Haur Kuo, Hsiu O. Ho

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32 Citations (Scopus)

Abstract

A new diterpene, 16-hydroxy communic acid (1), along with thirty one known compounds including five norditerpenes (2-6), twenty two flavonoids containing four biflavonoids (7-10), nine monoflavonoids (11-19) and nine flavanoid glycosides (20-28), as well as four phenolic constituents (29-32) were isolated from the 95% ethanolic extract of Podocarpus fasciculus. The structure of 1 was elucidated using spectral methods. Of these isolates, nagilactone C (2) showed the most significant inhibitory effects against DLD cells (human colon carcinoma) (ED50=2.57 μg/ml) and compounds 7, 8, 10, 11, and 12 had moderate cytotoxic activity against human KB (human oral epithelium carcinoma), Hela (human cervical carcinoma), Hepa (human hepatoma), DLD (colon carcinoma), and A-549 (human lung carcinoma) tumor cell lines. Preliminary structure-activity relationship studies of the isolated diterpenoids and biflavonoids are discussed.

Original languageEnglish
Pages (from-to)585-588
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume56
Issue number4
DOIs
Publication statusPublished - Apr 2008

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Keywords

  • 16-hydroxy communic acid
  • Cytotoxic activity
  • Podocarpaceae
  • Podocarpus fasciculus

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Kuo, Y. J., Hwang, S. Y., Wu, M. D., Liao, C. C., Liang, Y. H., Kuo, Y. H., & Ho, H. O. (2008). Cytotoxic constituents from Podocarpus fasciculus. Chemical and Pharmaceutical Bulletin, 56(4), 585-588. https://doi.org/10.1248/cpb.56.585