Cytotoxic constituents from Podocarpus fasciculus

Yu Jen Kuo, Shy Yuan Hwang, Ming Der Wu, Chia Ching Liao, Yu Han Liang, Yao Haur Kuo, Hsiu O. Ho

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

A new diterpene, 16-hydroxy communic acid (1), along with thirty one known compounds including five norditerpenes (2-6), twenty two flavonoids containing four biflavonoids (7-10), nine monoflavonoids (11-19) and nine flavanoid glycosides (20-28), as well as four phenolic constituents (29-32) were isolated from the 95% ethanolic extract of Podocarpus fasciculus. The structure of 1 was elucidated using spectral methods. Of these isolates, nagilactone C (2) showed the most significant inhibitory effects against DLD cells (human colon carcinoma) (ED50=2.57 μg/ml) and compounds 7, 8, 10, 11, and 12 had moderate cytotoxic activity against human KB (human oral epithelium carcinoma), Hela (human cervical carcinoma), Hepa (human hepatoma), DLD (colon carcinoma), and A-549 (human lung carcinoma) tumor cell lines. Preliminary structure-activity relationship studies of the isolated diterpenoids and biflavonoids are discussed.

Original languageEnglish
Pages (from-to)585-588
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume56
Issue number4
DOIs
Publication statusPublished - Apr 2008

Fingerprint

Diterpenes
Biflavonoids
Carcinoma
Glycosides
Colon
Flavonoids
Tumors
Cells
Structure-Activity Relationship
Tumor Cell Line
Human Activities
Hepatocellular Carcinoma
Epithelium
Lung

Keywords

  • 16-hydroxy communic acid
  • Cytotoxic activity
  • Podocarpaceae
  • Podocarpus fasciculus

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Kuo, Y. J., Hwang, S. Y., Wu, M. D., Liao, C. C., Liang, Y. H., Kuo, Y. H., & Ho, H. O. (2008). Cytotoxic constituents from Podocarpus fasciculus. Chemical and Pharmaceutical Bulletin, 56(4), 585-588. https://doi.org/10.1248/cpb.56.585

Cytotoxic constituents from Podocarpus fasciculus. / Kuo, Yu Jen; Hwang, Shy Yuan; Wu, Ming Der; Liao, Chia Ching; Liang, Yu Han; Kuo, Yao Haur; Ho, Hsiu O.

In: Chemical and Pharmaceutical Bulletin, Vol. 56, No. 4, 04.2008, p. 585-588.

Research output: Contribution to journalArticle

Kuo, YJ, Hwang, SY, Wu, MD, Liao, CC, Liang, YH, Kuo, YH & Ho, HO 2008, 'Cytotoxic constituents from Podocarpus fasciculus', Chemical and Pharmaceutical Bulletin, vol. 56, no. 4, pp. 585-588. https://doi.org/10.1248/cpb.56.585
Kuo YJ, Hwang SY, Wu MD, Liao CC, Liang YH, Kuo YH et al. Cytotoxic constituents from Podocarpus fasciculus. Chemical and Pharmaceutical Bulletin. 2008 Apr;56(4):585-588. https://doi.org/10.1248/cpb.56.585
Kuo, Yu Jen ; Hwang, Shy Yuan ; Wu, Ming Der ; Liao, Chia Ching ; Liang, Yu Han ; Kuo, Yao Haur ; Ho, Hsiu O. / Cytotoxic constituents from Podocarpus fasciculus. In: Chemical and Pharmaceutical Bulletin. 2008 ; Vol. 56, No. 4. pp. 585-588.
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