Cytotoxic apigenin derivatives from Chrysopogon aciculatis

Chien Chang Shen, Jing Jy Cheng, Horng Liang Lay, Szu Yuan Wu, Ching Li Ni, Che Ming Teng, Chien Chih Chen

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12 Citations (Scopus)


Four new apigenin derivatives, 7-de-O-methylaciculatin (1), 8-C-β-d-boivinopyranosylapigenin (2), aciculatinone (3), and 4′-O-glucosylaciculatin (4), along with eight known compounds, apigenin-8-carbaldehyde (5), kaempferol, tricin, taxifolin, 6,7,4′- trihydroxyflavone, trans-oxyresveratrol, aciculatin, and luteolin-7-sulfate, were isolated from an ethanolic extract of Chrysopogon aciculatis. Their chemical structures were elucidated by spectroscopic methods. Among the known compounds, the natural occurrence of apigenin-8-carbaldehyde and luteolin-7-sulfate is demonstrated for the first time. Some of the isolates were evaluated for cytotoxic activity against human cancer cell lines including MCF-7, H460, HT-29, and CEM.

Original languageEnglish
Pages (from-to)198-201
Number of pages4
JournalJournal of Natural Products
Issue number2
Publication statusPublished - Feb 24 2012
Externally publishedYes

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

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  • Cite this

    Shen, C. C., Cheng, J. J., Lay, H. L., Wu, S. Y., Ni, C. L., Teng, C. M., & Chen, C. C. (2012). Cytotoxic apigenin derivatives from Chrysopogon aciculatis. Journal of Natural Products, 75(2), 198-201.