Cytoprotection by propolis ethanol extract of acute absolute ethanol-induced gastric mucosal lesions

Chi Feng Liu, Chun Ching Lin, Mei Hsiu Lin, Yi Shiu Lin, Song Chow Lin

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Acute p.o. administration of absolute ethanol (1.0 ml/kg) to fasted rats produced extensive necrosis of gastric mucosa. Pretreatment with p.o. administration of propolis ethanol extract (PEE) could effectively and dose-dependently prevent such necrosis. This protective effect is called "cytoprotection." The maximal cytoprotective effect against absolute ethanol (AE)-induced gastric mucosal lesion was observed 1 hour after PEE administration. A gross examination of the gastric mucosa showed a marked improvement in groups receiving PEE. In order to further investigate the gastric protective mechanism of PEE, lipid peroxidation (LPO) levels in vivo and in vitro were estimated. PEE exhibited dose-dependent superoxide scavenging activity and antioxidant effects on AE-induced LPO in rat gastric mucosal homogenates. It was concluded that the gastric protective mechanism of PEE was due, at least in part, to its ability to inhibit LPO, and hence indirectly protect the gastric mucosa from oxidative stress.

Original languageEnglish
Pages (from-to)245-254
Number of pages10
JournalAmerican Journal of Chinese Medicine
Volume30
Issue number2-3
DOIs
Publication statusPublished - 2002

Keywords

  • Cytoprotection
  • Gastric Mucosal Lesion
  • Lipid Peroxidation
  • Propolis Ethanol Extract

ASJC Scopus subject areas

  • Complementary and alternative medicine

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