Cytokine MIF Enhances Blood-Brain Barrier Permeability: Impact for Therapy in Ischemic Stroke

Yu Chuan Liu, Yung Hsu Tsai, Sung Chun Tang, Houng Chi Liou, Kai Hsiang Kang, Horng Huei Liou, Jiann Shing Jeng, Wen Mei Fu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Ischemic stroke is a devastating disease with limited therapeutic options. It is very urgent to find a new target for drug development. Here we found that the blood level of MIF in ischemic stroke patients is upregulated. To figure out the pathological role of MIF in ischemic stroke, both in vitro and in vivo studies were conducted. For in vitro studies, primary cortical neuron cultures and adult rat brain endothelial cells (ARBECs) were subjected to oxygen-glucose deprivation (OGD)/reoxygenation. Middle cerebral artery occlusion (MCAo) rodent models were used for in vivo studies. The results show that MIF exerts no direct neuronal toxicity in primary culture but disrupts tight junction in ARBECs. Furthermore, administration of MIF following MCAo shows the deleterious influence on stroke-induced injury by destroying the tight junction of blood-brain barrier and increasing the infarct size. In contrast, administration of MIF antagonist ISO-1 has the profound neuroprotective effect. Our results demonstrate that MIF might be a good drug target for the therapy of stroke.

Original languageEnglish
Article number743
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - Dec 1 2018
Externally publishedYes

ASJC Scopus subject areas

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    Liu, Y. C., Tsai, Y. H., Tang, S. C., Liou, H. C., Kang, K. H., Liou, H. H., Jeng, J. S., & Fu, W. M. (2018). Cytokine MIF Enhances Blood-Brain Barrier Permeability: Impact for Therapy in Ischemic Stroke. Scientific Reports, 8(1), [743]. https://doi.org/10.1038/s41598-017-16927-9