CYTOGENETICALLY ABNORMAL CELL S IN VITRO IN ACUTE LEUKÆMIA

M. J. Duttera, J. M.C. Bull, J. Whang-Peng, P. P. Carbone

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Abstract

Twenty patients with previously identified direct cytogenetic abnormalities were examined for persistence of the abnormality in both direct bone-marrow preparations and in-vitro methylcellulose cultures. Of seven patients with persistent direct abnormalities, four had these same cytogenetic abnormalities identified in cells from culture. In three patients with acute myelocytic leukæmia or a variant, these abnormalities had been previously associated with leukæmic cell lines. Cytogenetic markers in the cultured cells indicate that leukæmic cells from some patients can be grown in vitro.

Original languageEnglish
Pages (from-to)715-718
Number of pages4
JournalThe Lancet
Volume299
Issue number7753
DOIs
Publication statusPublished - Apr 1 1972
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

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