Cytogenetic studies of 21 patients with acute lymphoblastic leukemia in relapse

L. M. Secker-Walker, G. Alimena, C. D. Bloomfield, Y. Kaneko, J. Whang-Peng, D. C. Arthur, A. de la Chapelle, B. R. Reeves, J. D. Rowley, S. D. Lawler, F. Mitelman

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Karyotypes of 21 patients, originally entered into the Third International Workshop on Chromosomes in Leukemia (3IWCL), were investigated in first, second and/or subsequent relapses. Karyotypes at diagnosis were related to the relapses in the following ways: normal to normal (N-N) (five cases); abnormal to normal (A-N) (two cases); abnormal to abnormal with no change (A-A) (five cases); abnormal to abnormal with clonal evolution (A-A+) (eight cases); and normal to abnormal (N-A) (one case). The A-A group comprised two each of t(4;11) and t(9;22) cases and one pseudodiploid case; included in this group were the only two patients who did not receive intensive treatment. Both A-N cases had been pseudodiploid at diagnosis. Clonal evolution A-A+ occurred in patients who had had 47-49 chromosomes or pseudodiploidy at diagnosis and was mainly due to the addition of structural change. The additional abnormalities were different in each case. The only de novo appearance of a clone (N-A) was in host cells in relapse following bone marrow transplantation. Clonal evolution occurred in patients who had been intensively treated and who relapsed late; the median time from diagnosis to relapse studied for the A-A group was 6 months and for the A-A+ group was 24 months. Survival following relapse was shorter for patients who had had a clonal abnormality at any time (median 10 months) than for those with no abnormality at diagnosis or in relapse (median 26 months).

Original languageEnglish
Pages (from-to)163-169
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume40
Issue number2
DOIs
Publication statusPublished - Jul 15 1989
Externally publishedYes

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Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cytogenetics
Clonal Evolution
Recurrence
Karyotype
Chromosomes
Bone Marrow Transplantation
Leukemia
Clone Cells
Education
Survival

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Secker-Walker, L. M., Alimena, G., Bloomfield, C. D., Kaneko, Y., Whang-Peng, J., Arthur, D. C., ... Mitelman, F. (1989). Cytogenetic studies of 21 patients with acute lymphoblastic leukemia in relapse. Cancer Genetics and Cytogenetics, 40(2), 163-169. https://doi.org/10.1016/0165-4608(89)90022-8

Cytogenetic studies of 21 patients with acute lymphoblastic leukemia in relapse. / Secker-Walker, L. M.; Alimena, G.; Bloomfield, C. D.; Kaneko, Y.; Whang-Peng, J.; Arthur, D. C.; de la Chapelle, A.; Reeves, B. R.; Rowley, J. D.; Lawler, S. D.; Mitelman, F.

In: Cancer Genetics and Cytogenetics, Vol. 40, No. 2, 15.07.1989, p. 163-169.

Research output: Contribution to journalArticle

Secker-Walker, LM, Alimena, G, Bloomfield, CD, Kaneko, Y, Whang-Peng, J, Arthur, DC, de la Chapelle, A, Reeves, BR, Rowley, JD, Lawler, SD & Mitelman, F 1989, 'Cytogenetic studies of 21 patients with acute lymphoblastic leukemia in relapse', Cancer Genetics and Cytogenetics, vol. 40, no. 2, pp. 163-169. https://doi.org/10.1016/0165-4608(89)90022-8
Secker-Walker, L. M. ; Alimena, G. ; Bloomfield, C. D. ; Kaneko, Y. ; Whang-Peng, J. ; Arthur, D. C. ; de la Chapelle, A. ; Reeves, B. R. ; Rowley, J. D. ; Lawler, S. D. ; Mitelman, F. / Cytogenetic studies of 21 patients with acute lymphoblastic leukemia in relapse. In: Cancer Genetics and Cytogenetics. 1989 ; Vol. 40, No. 2. pp. 163-169.
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AU - Arthur, D. C.

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