Cytogenetic studies in human T-cell lymphoma virus (HTLV)-positive leukemia-lymphoma in the United States

J. Whang-Peng, P. A. Bunn, T. Knutsen, C. S. Kao-Shan, S. Broder, E. S. Jaffe, E. Gelmann, W. Blattner, W. Lofters, R. C. Young

Research output: Contribution to journalArticle

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Abstract

Cytogenetic studies were conducted on fresh and cultured cells from 11 patients with human T-cell leukemia virus-associated adult T cell leukemia-lymphoma. Clones with abnormal karyotypes were detected in 9 of the 11 patients. Chromosome numbers were near-diploid in cells from all but 1 patient who also had a tetraploid clone. The chromosome abnormalities in these cells were extensive; numerous complex structural changes were seen in every chromosome pair. Structural abnormalities occurred frequently in chromosome 6. The 6 patients with chromosome 6 deletions had breakpoints at bands q11, q13, q16q23, q21q23, q22q24, and q23q24. The characteristic clinical features of these 6 patients were aggressive course, short survival, poor response to chemotherapy, high white blood cell counts, hypercalcemia, and bone lesions, whereas cytogenetically abnormal patients without chromosome 6q deletions tended to have a more indolent course. The precise role of the 6q deletion cannot be established with certainty from these data. However, this abnormality appears to occur with a greater than expected frequency in this large cell aggressive lymphoma, in association with hypercalcemia and lytic bone lesions.

Original languageEnglish
Pages (from-to)357-369
Number of pages13
JournalJournal of the National Cancer Institute
Volume74
Issue number2
Publication statusPublished - Jul 4 1985
Externally publishedYes

Fingerprint

Deltaretrovirus
Cytogenetics
Lymphoma
Chromosome Deletion
Chromosomes, Human, Pair 6
Hypercalcemia
Clone Cells
Chromosomes
Abnormal Karyotype
Bone and Bones
Adult T Cell Leukemia Lymphoma
Tetraploidy
Diploidy
Leukocyte Count
Chromosome Aberrations
Cultured Cells
Drug Therapy
Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Whang-Peng, J., Bunn, P. A., Knutsen, T., Kao-Shan, C. S., Broder, S., Jaffe, E. S., ... Young, R. C. (1985). Cytogenetic studies in human T-cell lymphoma virus (HTLV)-positive leukemia-lymphoma in the United States. Journal of the National Cancer Institute, 74(2), 357-369.

Cytogenetic studies in human T-cell lymphoma virus (HTLV)-positive leukemia-lymphoma in the United States. / Whang-Peng, J.; Bunn, P. A.; Knutsen, T.; Kao-Shan, C. S.; Broder, S.; Jaffe, E. S.; Gelmann, E.; Blattner, W.; Lofters, W.; Young, R. C.

In: Journal of the National Cancer Institute, Vol. 74, No. 2, 04.07.1985, p. 357-369.

Research output: Contribution to journalArticle

Whang-Peng, J, Bunn, PA, Knutsen, T, Kao-Shan, CS, Broder, S, Jaffe, ES, Gelmann, E, Blattner, W, Lofters, W & Young, RC 1985, 'Cytogenetic studies in human T-cell lymphoma virus (HTLV)-positive leukemia-lymphoma in the United States', Journal of the National Cancer Institute, vol. 74, no. 2, pp. 357-369.
Whang-Peng, J. ; Bunn, P. A. ; Knutsen, T. ; Kao-Shan, C. S. ; Broder, S. ; Jaffe, E. S. ; Gelmann, E. ; Blattner, W. ; Lofters, W. ; Young, R. C. / Cytogenetic studies in human T-cell lymphoma virus (HTLV)-positive leukemia-lymphoma in the United States. In: Journal of the National Cancer Institute. 1985 ; Vol. 74, No. 2. pp. 357-369.
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