Cytogenetic studies and clinical implications in patients with Sézary syndrome

J. Whang‐Peng, M. Lutzner, R. Edelson, T. Knutsen

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Chromosome studies were carried out on 11 National Institutes of Health (N.I.H.) patients who had the diagnosis of Sézary syndrome. Heteroploidy, multiple markers including minute and ring chromosomes, and a lack of modality and clone formation, were the common chromosomal findings in this syndrome. Abundant spontaneous division of heteroploid cells in unstimulated peripheral blood cultures, a high percentage of heteroploid cells in stimulated culture, and finally, clone formation, are signs of a fulminant process and lead to the terminal phase of this disease. Early chemotherapeutic eradication of these heteroploid neoplastic cells would, therefore, be the treatment of choice in this disease.

Original languageEnglish
Pages (from-to)861-867
Number of pages7
JournalCancer
Volume38
Issue number2
DOIs
Publication statusPublished - Jan 1 1976
Externally publishedYes

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Cytogenetics
Clone Cells
Ring Chromosomes
National Institutes of Health (U.S.)
Cell Division
Chromosomes
Clinical Studies
Therapeutics
Blood Culture

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Cytogenetic studies and clinical implications in patients with Sézary syndrome. / Whang‐Peng, J.; Lutzner, M.; Edelson, R.; Knutsen, T.

In: Cancer, Vol. 38, No. 2, 01.01.1976, p. 861-867.

Research output: Contribution to journalArticle

Whang‐Peng, J. ; Lutzner, M. ; Edelson, R. ; Knutsen, T. / Cytogenetic studies and clinical implications in patients with Sézary syndrome. In: Cancer. 1976 ; Vol. 38, No. 2. pp. 861-867.
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