Cytogenetic characterization of selected small round cell tumors of childhood

J. Whang-Peng, T. J. Triche, T. Knutsen, J. Miser, S. Kao-Shan, S. Tsai, M. A. Israel

Research output: Contribution to journalArticle

264 Citations (Scopus)

Abstract

Small, round, blue-cell tumors (SRCT), including rhabdomyosarcoma, Ewing's sarcoma of bone and soft tissue, mesenchymal chondrosarcoma, small cell osteosarcoma, hemangiopericytoma, neuroblastoma, peripheral neurectodermal tumor (peripheral neuroepithelioma of bone and soft tissue), and the malignant small cell tumor of the thoracopulmonary region described by Askin (Askin's tumor), are often difficult to distinguish by light microscopy. We have evaluated the cytogenetics of these tumors by studying 24 tumor explants in short-term culture and 22 tumor cell lines. In Ewing's sarcoma (a tumor of unknown histogenesis), and in peripheral neuroepithelioma and Askin's tumor (tumors with evidence of neural origin), we have observed an indistinguishable t(11;22) translocation.

Original languageEnglish
Pages (from-to)185-208
Number of pages24
JournalCancer Genetics and Cytogenetics
Volume21
Issue number3
DOIs
Publication statusPublished - Apr 1 1986
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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