Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis

Jeng Hsien Yen, Wen Chun Tsai, Chung J. Chen, Chia H. Lin, Tsan Teng Ou, Chaur Jong Hu, Hong W. Liu

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objectives: To investigate the associations of cytochrome p450 1A1 (CYP1A1) and manganese superoxide dismutase (MnSOD) genes polymorphisms with the susceptibility to AS in Taiwan. Methods: The polymorphisms of CYP1A1 and MnSOD genes were determined in 70 patients with ankylosing spondylitis (AS) and 93 healthy controls by polymerase chain reaction (PCR)/restriction fragment length polymorphisms (RFLP) methods. Results: The genotype frequency of CYP1A1 4887C/A was significantly lower in patients with AS than in controls. The phenotype frequency of CYP1A1 4887A also tended to be decreased in patients with AS. There were no significant differences in the genotype, allele, and phenotype frequencies of MnSOD gene polymorphisms between patients with AS and controls. Conclusion: CYP1A1 4887A may be a protective factor for the development of AS in Taiwan. However, MnSOD gene polymorphisms are not associated with the susceptibility to AS.

Original languageEnglish
Pages (from-to)113-116
Number of pages4
JournalImmunology Letters
Volume88
Issue number2
DOIs
Publication statusPublished - Aug 5 2003
Externally publishedYes

Fingerprint

Ankylosing Spondylitis
Cytochrome P-450 Enzyme System
Superoxide Dismutase
Genes
Taiwan
Genotype
Phenotype
Gene Frequency
Restriction Fragment Length Polymorphisms
Polymerase Chain Reaction

Keywords

  • Ankylosing spondylitis
  • Cytochrome
  • Manganese superoxide dismutase

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis. / Yen, Jeng Hsien; Tsai, Wen Chun; Chen, Chung J.; Lin, Chia H.; Ou, Tsan Teng; Hu, Chaur Jong; Liu, Hong W.

In: Immunology Letters, Vol. 88, No. 2, 05.08.2003, p. 113-116.

Research output: Contribution to journalArticle

Yen, Jeng Hsien ; Tsai, Wen Chun ; Chen, Chung J. ; Lin, Chia H. ; Ou, Tsan Teng ; Hu, Chaur Jong ; Liu, Hong W. / Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis. In: Immunology Letters. 2003 ; Vol. 88, No. 2. pp. 113-116.
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AU - Ou, Tsan Teng

AU - Hu, Chaur Jong

AU - Liu, Hong W.

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AB - Objectives: To investigate the associations of cytochrome p450 1A1 (CYP1A1) and manganese superoxide dismutase (MnSOD) genes polymorphisms with the susceptibility to AS in Taiwan. Methods: The polymorphisms of CYP1A1 and MnSOD genes were determined in 70 patients with ankylosing spondylitis (AS) and 93 healthy controls by polymerase chain reaction (PCR)/restriction fragment length polymorphisms (RFLP) methods. Results: The genotype frequency of CYP1A1 4887C/A was significantly lower in patients with AS than in controls. The phenotype frequency of CYP1A1 4887A also tended to be decreased in patients with AS. There were no significant differences in the genotype, allele, and phenotype frequencies of MnSOD gene polymorphisms between patients with AS and controls. Conclusion: CYP1A1 4887A may be a protective factor for the development of AS in Taiwan. However, MnSOD gene polymorphisms are not associated with the susceptibility to AS.

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