CYP19 TCT Tri-Nucleotide Del/Del Genotype Is a Susceptibility Marker for Prostate Cancer in a Taiwanese Population

Yu Chuen Huang, Marcelo Chen, Ming Wei Lin, Ming Yi Chung, Yen Hwa Chang, William Ji Shian Huang, Tony T. Wu, Jong Ming Hsu, Stone Yang, Yi Ming Arthur Chen

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9 Citations (Scopus)

Abstract

Objectives: The CYP19 gene encodes aromatase-a key enzyme involved in the conversion of androstenedione/testosterone to estrone/estradiol. In this study, we analyzed the association between the TCT insertion (Ins)/deletion (Del) and TTTA repeat polymorphisms of CYP19 and prostate cancer (PCa). Methods: Automated sequencer with GeneScan software was used to determine the CYP19 gene polymorphisms in peripheral blood mononuclear cell DNA from 244 patients with PCa and 261 age-matched healthy male controls. The distribution of Stage I to IV was 3.4%, 23.8%, 19.6%, and 53.2%, respectively. The Gleason score was 2 to 5 in 22.9%, 6 to 7 in 53.2%, and 8 to 10 in 23.8%. Results: The frequency of the TCT Del/Del genotype in the Taiwanese patients with PCa (12.3%) was significantly greater than that in the controls (5.4%; P = 0.015, odds ratio [OR] 2.43, 95% confidence interval [CI] 1.23 to 4.80). Individuals with a homozygous A1 (seven TTTA repeats) genotype had a significantly greater risk of developing PCa (OR 1.59, 95% CI 1.04 to 2.44, P = 0.044). The frequency of the Ins-A6 (12 TTTA repeats) haplotype was significantly greater in the control group than in the patient group (9.8% versus 6.1%, OR 0.61, 95% CI 0.38 to 0.97). The OR of developing PCa for men with the homozygous Del-A1 diplotype was 2.31 (95% CI 1.10 to 4.83). Conclusions: The results of our study have shown that the CYP19 TCT Del/Del genotype might be a susceptibility marker for PCa. Men with the Ins-A6 haplotype had a lower risk of developing PCa.

Original languageEnglish
Pages (from-to)996-1000
Number of pages5
JournalUrology
Volume69
Issue number5
DOIs
Publication statusPublished - May 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Urology

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    Huang, Y. C., Chen, M., Lin, M. W., Chung, M. Y., Chang, Y. H., Huang, W. J. S., Wu, T. T., Hsu, J. M., Yang, S., & Chen, Y. M. A. (2007). CYP19 TCT Tri-Nucleotide Del/Del Genotype Is a Susceptibility Marker for Prostate Cancer in a Taiwanese Population. Urology, 69(5), 996-1000. https://doi.org/10.1016/j.urology.2007.02.014