CyclinD1 protein expressed in pterygia is associated with β-catenin protein localization

Jai Nien Tung, Chun Chi Chiang, Yi Yu Tsai, Ying Yi Chou, Kun Tu Yeh, Huei Lee, Ya Wen Cheng

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20 Citations (Scopus)

Abstract

Background: The Wnt (Wg/Wnt) signaling cascade plays an important role in tumorigenesis. Our previous report indicated that aberrant localization of β-catenin proteins was a feature of pterygia. Therefore, this study aimed to analyze the association of β-catenin protein and expression of a downstream gene, cyclin D1, in pterygial tissues. Methods: Using immunohistochemistry, β-catenin and cyclin D1 protein expression was studied, in 150 pterygial specimens and 30 normal conjunctivas. Results: Seventy-three (48.7%) and 60 (40.0%) pterygial specimens tested positive for β-catenin and cyclin D1 protein expression, respectively. Cyclin D1protein expression was significantly higher in β-catenin-nuclear/cytoplasmic positive groups than in β-catenin membrane positive and negative groups (p<0.0001). In addition, cyclin D1 expression was significantly higher in the fleshy group than in the atrophic and intermediate groups (p=0.006). Conclusions: Our study demonstrated that β-catenin expressed in nuclei/cytoplasm increases cyclinD1 protein expression, which invokes pterygial cell proliferation. © 2010 Molecular Vision.

Original languageEnglish
Pages (from-to)2733-2738
Number of pages6
JournalMolecular Vision
Volume16
Publication statusPublished - 2010
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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    Tung, J. N., Chiang, C. C., Tsai, Y. Y., Chou, Y. Y., Yeh, K. T., Lee, H., & Cheng, Y. W. (2010). CyclinD1 protein expressed in pterygia is associated with β-catenin protein localization. Molecular Vision, 16, 2733-2738.