Cushings disease in children: Report of three cases

Ping Yi Hsu, Yi Ching Tung, Cheng Ting Lee, Fu Sung Lo, Mu Zon Wu, Wen Yu Tsai, Yong Kwang Tu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cushings disease is rare in children and adolescents. We report the clinical presentations of three children with Cushings disease. All three exhibited the typical symptoms and signs of weight gain and growth retardation. Tw o also demonstrated personality changes, hypertension and hypokalemia, the last of these being rarely reported in patients with Cushings disease. Lack of diurnal changes in serum cortisol levels was the most common biochemical finding. Serum cortisol levels were suppressed by low-dose dexamethasone in one patient, which is not typical for patients with Cushings disease. Imaging studies are essential for localizing the tumor. Transsphenoidal surgery remains the treatment of choice, and pituitary irradiation should be considered for those patients whose tumors cannot be totally removed. Careful follow-up of these patients with awareness of the possibilities of relapse and the complications of hypopituitarism is indicated.

Original languageEnglish
Pages (from-to)303-307
Number of pages5
JournalPediatrics and Neonatology
Volume51
Issue number5
DOIs
Publication statusPublished - Oct 1 2010
Externally publishedYes

Keywords

  • Cushings disease
  • Cushings syndrome
  • Hypokalemia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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