Curcumin reduces pulmonary tumorigenesis in vascular endothelial growth factor (VEGF)-overexpressing transgenic mice

Yu Tang Tung, Hsiao Ling Chen, Cheng Wei Lai, Chih Jie Shen, Yi Wen Lai, Chuan Mu Chen

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Scope: We investigated the inhibition of pulmonary tumor formation through treatment with curcumin in transgenic mice. Methods and results: In this study, a strain of transgenic mice carrying human vascular endothelial growth factor A165 (hVEGF-A165) gene to induce pulmonary tumor was used as an in vivo cancer therapy model. We found that curcumin significantly reduced hVEGF-A165 overexpression to normal, specifically in Clara cells of the lungs of transgenic mice, and suppressed the formation of tumors. In addition, we demonstrated a relationship between curcumin treatment and the expression of VEGF, EGFR, ERK2, and Cyclin A at the transcriptional and translational levels. We also noticed a reduction of Cyclin A and Cyclin B after curcumin treatment that had an effect on the cell cycle. Curcumin-induced inhibition of Cyclin A and Cyclin B likely results in decreased progression through S and G2/M phases. These results demonstrated that the expression of proteins involved in the S to M phase transition in transgenic mice is suppressed by curcumin. Conclusion: A Data suggest that a blockade of the cell cycle may be a critical mechanism for the observed effects on vasculogenesis and angiogenesis following treatment with curcumin.

Original languageEnglish
Pages (from-to)1036-1043
Number of pages8
JournalMolecular Nutrition and Food Research
Volume55
Issue number7
DOIs
Publication statusPublished - Jul 2011
Externally publishedYes

Fingerprint

Curcumin
curcumin
vascular endothelial growth factors
carcinogenesis
Vascular Endothelial Growth Factor A
Transgenic Mice
Carcinogenesis
cyclins
lungs
genetically modified organisms
Lung
mice
Cyclin A
Cyclin B
lung neoplasms
Cell Division
mitosis
cell cycle
Neoplasms
Cell Cycle

Keywords

  • Curcumin
  • Pulmonary cancer
  • Transgenic mice
  • Turmeric
  • VEGF

ASJC Scopus subject areas

  • Biotechnology
  • Food Science

Cite this

Curcumin reduces pulmonary tumorigenesis in vascular endothelial growth factor (VEGF)-overexpressing transgenic mice. / Tung, Yu Tang; Chen, Hsiao Ling; Lai, Cheng Wei; Shen, Chih Jie; Lai, Yi Wen; Chen, Chuan Mu.

In: Molecular Nutrition and Food Research, Vol. 55, No. 7, 07.2011, p. 1036-1043.

Research output: Contribution to journalArticle

Tung, Yu Tang ; Chen, Hsiao Ling ; Lai, Cheng Wei ; Shen, Chih Jie ; Lai, Yi Wen ; Chen, Chuan Mu. / Curcumin reduces pulmonary tumorigenesis in vascular endothelial growth factor (VEGF)-overexpressing transgenic mice. In: Molecular Nutrition and Food Research. 2011 ; Vol. 55, No. 7. pp. 1036-1043.
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