Curcumin nanoparticles improve the physicochemical properties of curcumin and effectively enhance its antioxidant and antihepatoma activities

Feng Lin Yen, Tzu Hui Wu, Cheng Wei Tzeng, Liang Tzung Lin, Chun Ching Lin

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158 Citations (Scopus)

Abstract

Curcumin (CUR), a natural polyphenol isolated from tumeric (Curcuma longa), has been documented to possess antioxidant and anticancer activities. Unfortunately, the compound has poor aqueous solubility, which results in poor bioavailability following high doses by oral administration. To improve the solubility of CUR, we developed a novel curcumin nanoparticle system (CURN) and investigated its physicochemical properties as well as its enhanced dissolution mechanism. Our results indicated that CURN improved the physicochemical properties of CUR, including a reduction in particle size and the formation of an amorphous state with hydrogen bonding, both of which increased the drug release of the compound. Moreover, in vitro studies indicated that CURN significantly enhanced the antioxidant and antihepatoma activities of CUR (P <0.05). Consequently, we suggest that CURN can be used to reduce the dosage of CUR and improve its bioavailability and merits further investigation for therapeutic applications.

Original languageEnglish
Pages (from-to)7376-7382
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Volume58
Issue number12
DOIs
Publication statusPublished - Jun 23 2010
Externally publishedYes

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Keywords

  • Antihepatoma
  • Antioxidant
  • Curcumin
  • Nanoparticle
  • Physicochemical properties

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)
  • Medicine(all)

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