Curcumin-laden dual-targeting fucoidan/chitosan nanocarriers for inhibiting brain inflammation via intranasal delivery

Trong Ming Don, Wan Ju Chang, Pei Ru Jheng, Yi Cheng Huang, Er Yuan Chuang

Research output: Contribution to journalArticlepeer-review

Abstract

Curcumin can reduce the production of brain inflammatory mediators and symptoms of brain diseases. However, a large amount of free curcumin needs to be administered to achieve an effective level in the brain because of its poor water-solubility. Fucoidan and chitosan were reported to respectively target P-selectin and acidic microenvironment expressed by pathologically inflammatory cells/tissues. Herein, the self-assembly of chitosan and fucoidan which could encapsulate curcumin was developed to form the multi-stimuli-responsive nanocarriers, and their pathological pH- and P-selectin-responsive aspects were characterized. Through intranasal delivery to the brain, these curcumin-containing chitosan/fucoidan nanocarriers with dual pH-/P-selectin-targeting properties to the brain lesions improved drug delivery, distribution, and accumulation in the inflammatory brain lesions as evidenced by an augmented inhibitory effect against brain inflammation. This promising multifunctional nanocarrier with a novel drug-delivery route should allow potential clinical biomedical uses by neurosurgeon in the future.

Original languageEnglish
Pages (from-to)835-846
Number of pages12
JournalInternational Journal of Biological Macromolecules
Volume181
DOIs
Publication statusPublished - Jun 2021

Keywords

  • Chitosan
  • Curcumin
  • Fucoidan
  • Intranasal to brain drug delivery
  • Multi-functional nanocarrier
  • Suppression of brain inflammatory

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Economics and Econometrics
  • Energy(all)

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