Cul 3-KLHL20 ubiquitin ligase

Physiological functions, stress responses, and disease implications

Hsin Yi Chen, Chin Chih Liu, Ruey Hwa Chen

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Cullin-RING ubiquitin ligases are the largest Ubiquitin ligase family in eukaryotes and are multi-protein complexes. In these complexes, the Cullin protein serves as a scaffold to connect two functional modules of the ligases, the catalytic subunit and substrate-binding subunit. KLHL20 is a substrate-binding subunit of Cullin3 (Cul3) ubiquitin ligase. Recent studies have identified a number of substrates of KLHL20-based ubiquitin ligase. Through ubiquitination of these substrates, KLHL20 elicits diverse cellular functions, some of which are associated with human diseases. Furthermore, the functions, subcellular localizations, and expression of KLHL20 are regulated by several physiological and stressed signals, which allow KLHL20 to preferentially act on certain substrates to response to these signals. Here, we provide a summary of the functions and regulations of KLHL20 in several physiological processes and stress responses and its disease implications.

Original languageEnglish
Article number5
JournalCell Division
Volume11
Issue number1
DOIs
Publication statusPublished - 2016

Fingerprint

Physiological Stress
Ligases
Ubiquitin
Cullin Proteins
Substrates
Physiological Phenomena
Ubiquitination
Eukaryota
Scaffolds
Catalytic Domain
Proteins

Keywords

  • Actin cytoskeleton
  • Angiogenesis
  • Autophagy
  • Cancer
  • Cul3 ubiquitin ligases
  • Hypoxia
  • KLHL20
  • Ubiquitination

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Cul 3-KLHL20 ubiquitin ligase : Physiological functions, stress responses, and disease implications. / Chen, Hsin Yi; Liu, Chin Chih; Chen, Ruey Hwa.

In: Cell Division, Vol. 11, No. 1, 5, 2016.

Research output: Contribution to journalReview article

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AU - Liu, Chin Chih

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KW - Actin cytoskeleton

KW - Angiogenesis

KW - Autophagy

KW - Cancer

KW - Cul3 ubiquitin ligases

KW - Hypoxia

KW - KLHL20

KW - Ubiquitination

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