CTLA-4, position 49 A/G polymorphism associated with coronary artery lesions in Kawasaki disease

Ho Chang Kuo, Chi Di Liang, Hong Ren Yu, Chih Lu Wang, I. Chun Lin, Chieh An Liu, Jen Chieh Chang, Chiu Ping Lee, Wei Chiao Chang, Kuender D. Yang

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21 Citations (Scopus)

Abstract

Objective: Kawasaki disease (KD) is a systemic vasculitis of unknown etiology and primarily affects children less than 5 years of age. Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) has been suggested as a candidate gene for conferring susceptibility to autoimmunity. This study examined the correlation of CTLA-4 gene polymorphisms in KD with and without coronary artery lesions (CAL). Materials and methods: A total of 233 KD patients and 644 controls were subjected to determination of CTLA-4 polymorphisms at (-318) C/T and (+49) A/G positions by restriction fragment length polymorphism. Susceptibility, CAL, and intravenous immunoglobulin treatment response of KD were then analyzed with genetic variants. Results: Polymorphisms of CTLA-4 (+49 A/G) and (-318 C/T) were not significantly different between normal children and patients with KD. The CTLA-4 (+49) A allele (AA+AG genotype), however, was significantly associated with CAL formation, especially in female patients. Conclusions: This study provides the first evidence supporting the association of CTLA-4 (+49) A/G polymorphism with the CAL formation of KD particularly in female patients.

Original languageEnglish
Pages (from-to)240-244
Number of pages5
JournalJournal of Clinical Immunology
Volume31
Issue number2
DOIs
Publication statusPublished - Apr 2011
Externally publishedYes

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Keywords

  • coronary artery lesions
  • CTLA-4
  • Kawasaki disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Kuo, H. C., Liang, C. D., Yu, H. R., Wang, C. L., Lin, I. C., Liu, C. A., Chang, J. C., Lee, C. P., Chang, W. C., & Yang, K. D. (2011). CTLA-4, position 49 A/G polymorphism associated with coronary artery lesions in Kawasaki disease. Journal of Clinical Immunology, 31(2), 240-244. https://doi.org/10.1007/s10875-010-9484-4