Crystal structure of a z-dna fragment containing thymine/2-aminoadenine base pairs

Miguel Coll, Andrew H.J. Wang, Gijs A. Van Der Marel, Jacques H. Van Boom, Alexander Rich

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

The Z-DNA structure has been shown to form in two crystals made from self-complementary DNA hexamers d(CGTDCG) and d(CDCGTG) which contain thymine/2-aminoadenine (TD) base pairs. The latter structure has been solved and refined to 1.3 Å resolution and it shows only small conformational changes due to the introduction of the TD base pairs in comparison with the structure of d(CG)3. Spectroscopic studies with these compounds demonstrate that DNA molecules containing 2-aminoadenine residues form Z-DNA slightly more easily than do those containing adenine nucleotides, but not as readily as the parent sequence containing only guanine-cytosine base pairs.

Original languageEnglish
Pages (from-to)157-172
Number of pages16
JournalJournal of Biomolecular Structure and Dynamics
Volume4
Issue number2
DOIs
Publication statusPublished - Oct 1986
Externally publishedYes

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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